OPPOSING EFFECTS OF DHEA REPLACEMENT IN ELDERLY SUBJECTS ON DECLARATIVE MEMORY AND ATTENTION AFTER EXPOSURE TO A LABORATORY STRESSOR

• Published in: Psychoneuroendocrinology Vol. 23; no. 6; pp. 617 - 629
• Main Authors: T. Wolf, Oliver, M. Kudielka, Brigitte, H. Hellhammer, Dirk, Hellhammer, Juliane, Kirschbaum, Clemens
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.08.1998; Elsevier
• Subjects: Aged; Aged, 80 and over; Aging; Attention; Attention - drug effects; Behavioral psychophysiology; Biological and medical sciences; Cognition - drug effects; Declarative memory; Dehydroepiandrosterone (DHEA) replacement; Dehydroepiandrosterone Sulfate - blood; Dehydroepiandrosterone Sulfate - metabolism; Dehydroepiandrosterone Sulfate - therapeutic use; Double-Blind Method; Female; Fundamental and applied biological sciences. Psychology; Hormone Replacement Therapy - psychology; Hormones and behavior; Humans; Male; Memory - drug effects; Middle Aged; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychomotor Performance - drug effects; Psychomotor Performance - physiology; Saliva - metabolism; Space Perception - drug effects; Space Perception - physiology; Stress; Stress, Psychological - psychology; Aging; Declarative memory; Humans; Dehydroepiandrosterone (DHEA) replacement; Stress; Attention; Human; Vigilance; Senescence; Visual memory; Steroid hormone; Memory; Cognition; Hydrocortisone; Glucocorticoid; Mental activity; Verbal memory; Dehydroepiandrosterone; Adrenal hormone; Developmental stage; Age

Aging is accompanied by a continuous decline of the adrenal steroid hormone DHEA and its ester DHEAS. Results from studies in rodents have demonstrated that DHEA(S) administration can enhance memory in several test paradigms. However studies from this laboratory did not find positive effects of DHEA...