Impact of air filtration on nosocomial aspergillus infections: Unique risk of bone marrow transplant recipients

• Published in: The American journal of medicine Vol. 83; no. 4; pp. 709 - 718
• Main Authors: Sherertz, Robert J., Belani, Anusha, Kramer, Barnett S., Elfenbein, Gerald J., Weiner, Roy S., Sullivan, Marsha L., Thomas, Ronald G., Samsa, Gregory P.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.1987; Elsevier
• Subjects: Air Microbiology; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Aspergillosis - etiology; Aspergillosis - prevention & control; Biological and medical sciences; Bone Marrow Transplantation; Bone marrow, stem cells transplantation. Graft versus host reaction; Cross Infection - etiology; Cross Infection - prevention & control; Environment, Controlled; Filtration - instrumentation; Humans; Immune Tolerance; Lung Diseases, Fungal - etiology; Lung Diseases, Fungal - prevention & control; Medical sciences; Risk Factors; Statistics as Topic; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Ventilation; Human; High risk; Homograft; Various treatments; Malignant hemopathy; Fungi; Infection; Prevention; Aspergillus; Autograft; Immunosuppression; Bone marrow; Tumor; Fungi Imperfecti; Thallophyta; Air filtration

Bone marrow transplant recipients were found to have a 10-fold greater incidence of nosocomial Aspergillus infection than other immunocompromised patient populations (p <0.001) when housed outside of a high-efficiency particulate air (HEPA) filtered environment. Multivariate analysis demonstrated...