Metabolomic Profiling Differences among Asthma, COPD, and Healthy Subjects: A LC-MS-based Metabolomic Analysis

• Published in: Biomedical and environmental sciences Vol. 32; no. 9; pp. 659 - 672
• Main Authors: LIANG, Ying, GAI, Xiao Yan, CHANG, Chun, ZHANG, Xu, WANG, Juan, LI, Ting Ting
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.09.2019; Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China%Tianjin Key Lab. of Metabolic Diseases and Department of Physiology, Tianjin Medical University, Tianjin 300070, China%Lab. of Respiratory Disease, Peking University Third Hospital, Beijing 100191, China%Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University Health Science Centre, Beijing 100191, China
• Subjects: Adult; Aged; Aged, 80 and over; Asthma; Asthma - metabolism; Beijing; Case-Control Studies; Chromatography, Liquid; Chronic obstructive pulmonary disease; Female; Humans; Liquid chromatography; Male; Mass spectrometry; Metabolome; Metabolomics; Middle Aged; Multivariate Analysis; Pulmonary Disease, Chronic Obstructive - metabolism; Serum - chemistry; Spectrometry, Mass, Electrospray Ionization; Beijing; Metabolomics; Chronic obstructive pulmonary disease; Liquid chromatography; Mass spectrometry; Asthma

Asthma and chronic obstructive pulmonary disease (COPD) feature different inflammatory and cellular profiles in the airways, indicating that the cellular metabolic pathways regulating these disorders are distinct. We aimed to compare the serum metabolomic profiles among mild persistent asthmatic pat...