Associations among oxidative stress, Lp-PLA2 activity and arterial stiffness according to blood pressure status at a 3.5-year follow-up in subjects with prehypertension

• Published in: Atherosclerosis Vol. 257; pp. 179 - 185
• Main Authors: Kim, Minkyung, Yoo, Hye Jin, Kim, Minjoo, Ahn, Hyeon Yeong, Park, Jiyeong, Lee, Sang-Hyun, Lee, Jong Ho
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.02.2017
• Subjects: Arterial stiffness; ba-PWV; Cardiovascular; Lp-PLA2; ox-LDL; Oxidative stress; Persistent prehypertension; Persistent prehypertension; Oxidative stress; ox-LDL; Arterial stiffness; ba-PWV; Lp-PLA2; Lp-PLA 2
• DOI: 10.1016/j.atherosclerosis.2017.01.006
• ISSN: 0021-9150; 1879-1484

We aimed to determine changes in oxidative stress, lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and arterial stiffness in subjects with persistent prehypertensive symptoms during a 3.5-year follow-up period. We divided 254 subjects with prehypertension according to their blood pressure (BP) status at 3.5 years of follow-up into three groups: reversed normotensive, persistent prehypertensive and developed hypertensive group. BP, serum lipid profile, oxidized LDL (ox-LDL), Lp-PLA2 activity and brachial-ankle pulse wave velocity (ba-PWV) were measured at baseline and the 3.5-year follow-up. The reversed normotensive group showed a significant reduction in average BP (14.7/10.1 mmHg), whereas the developed hypertensive group showed a significant increase in average BP (15.2/11.5 mmHg). The persistent prehypertensive group showed increases in serum lipid profiles, circulating levels of Lp-PLA2 activity, ox-LDL and arterial stiffness as measured by ba-PWV at 3.5 years. The persistent prehypertensive and developed hypertensive groups showed greater increases in ox-LDL than the reversed normotensive group. The developed hypertensive group showed greater increases in Lp-PLA2, 8-epi-PGF2α, and ba-PWV than those observed in the reversed normotensive and persistent prehypertensive groups. In all subjects, changes (Δ) in systolic blood pressure (SBP) positively correlated with Δ Lp-PLA2, Δ ox-LDL, Δ urinary 8-epi-PGF2α and Δ ba-PWV. This study indicates that in persistent prehypertension, increased ox-LDL hydrolysis by Lp-PLA2 enhances arterial stiffness without an age-related increase in BP. •Persistent prehypertensive group showed increases in Lp-PLA2, ox-LDL, and ba-PWV at 3.5 years.•Persistent prehypertensive group showed greater increases in ox-LDL and Lp-PLA2 than normotensive group.•Systolic blood pressure was positively correlated with Lp-PLA2, ox-LDL, 8-epi-PGF2α, and ba-PWV.•Increased ox-LDL hydrolysis by Lp-PLA2 may enhance arterial stiffness in persistent prehypertension without increase in BP.