Genetic and epigenetic alterations in normal and sensitive COPD-diseased human bronchial epithelial cells repeatedly exposed to air pollution-derived PM2.5

• Published in: Environmental pollution (1987) Vol. 230; pp. 163 - 177
• Main Authors: Leclercq, B., Platel, A., Antherieu, S., Alleman, L.Y., Hardy, E.M., Perdrix, E., Grova, N., Riffault, V., Appenzeller, B.M., Happillon, M., Nesslany, F., Coddeville, P., Lo-Guidice, J-M., Garçon, G.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.11.2017
• Subjects: acetylation; air; Air pollution-derived PM2.5; chromosome aberrations; DNA adducts; DNA damage; enzyme activity; epigenetics; epithelial cells; genes; Genetic and epigenetic hallmarks; Healthy and COPD phenotypes; histones; Human bronchial epithelial cells; humans; in vitro studies; lung neoplasms; metabolites; methylation; methyltransferases; particulates; patients; phenotype; phosphorylation; Sensitivity; telomerase; telomeres; Healthy and COPD phenotypes; Genetic and epigenetic hallmarks; Sensitivity; Air pollution-derived PM2.5; Human bronchial epithelial cells

Even though clinical, epidemiological and toxicological studies have progressively provided a better knowledge of the underlying mechanisms by which air pollution-derived particulate matter (PM) exerts its harmful health effects, further in vitro studies on relevant cell systems are still needed. He...