Antidepressant fluoxetine induces multiple antibiotics resistance in Escherichia coli via ROS-mediated mutagenesis

• Published in: Environment international Vol. 120; pp. 421 - 430
• Main Authors: Jin, Min, Lu, Ji, Chen, Zhaoyu, Nguyen, Son Hoang, Mao, Likai, Li, Junwen, Yuan, Zhiguo, Guo, Jianhua
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.11.2018
• Subjects: AcrAB-TolC; Anti-Bacterial Agents - pharmacology; Antidepressant fluoxetine; Antidepressive Agents - pharmacology; Antimicrobial resistance; Drug Resistance, Multiple, Bacterial - drug effects; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - physiology; Escherichia coli Proteins - metabolism; Fluoxetine - pharmacology; Membrane Transport Proteins - metabolism; Microbial Sensitivity Tests; Multiple antibiotic resistance; Mutagenesis; Proteomics; Reactive Oxygen Species - metabolism; ROS-mediated mutagenesis; ROS-mediated mutagenesis; Multiple antibiotic resistance; Antimicrobial resistance; Antidepressant fluoxetine; Escherichia coli; AcrAB-TolC

Antibiotic resistance poses a great threat to global public health. Overuse of antibiotics is generally considered as the major factor contributing to it. However, little is known about whether non-antibiotic drugs could play potential roles in the emergence of antibiotic resistance. We aimed to inv...