A novel hydrogen bonded bimetallic supramolecular coordination polymer {[SnMe3(bpe)][Ag(CN)2]·2H2O} as anticancer drug

• Published in: European journal of medicinal chemistry Vol. 46; no. 11; pp. 5370 - 5378
• Main Authors: Etaiw, Safaa El-din H., Sultan, Ahmed S., Badr El-din, Ahmed S.
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.11.2011
• Subjects: 1,2-Bis(4-pyridyl)ethane; Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antitumor activity; Cell Line, Tumor; Cell Survival - drug effects; Crystallography, X-Ray; Female; Fluorescence; Humans; Hydrogen Bonding; Hydrogen bonds; Models, Molecular; Molecular Conformation; Organotin Compounds - chemistry; Polymers - chemical synthesis; Polymers - chemistry; Polymers - pharmacology; Rats; Silver cyanide; Supramolecular coordination polymer; Temperature; Trimethyltin; Xenograft Model Antitumor Assays; Supramolecular coordination polymer; 1,2-Bis(4-pyridyl)ethane; Hydrogen bonds; Fluorescence; Antitumor activity; Silver cyanide; Trimethyltin
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2011.08.041

The reaction of Me3SnCl, K3[Ag(CN)4] and 1,2-bis(4-pyridyl)ethane (bpe) in water/CH3CN solution at room temperature affords the novel bimetallic supramolecular coordination polymer (SCP) {[SnMe3(bpe)] [Ag(CN)2]·2H2O}n, 1. The structure of 1 consists of cationic {–Sn(Me3)–bpe–}+ chains that are neutralized by [Ag(CN)2]− anions. The dicyanoargentate(I) anions present discrete uncoordinated fragments between the cationic chains. The water molecules bind the cationic chains and the anions forming 3D-supramolecular structure through hydrogen bonds. 1 exhibits strong fluorescence in the solid state at room temperature. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the in vitro antitumor effects of the SCP 1 on human breast cancer cell line, T-47D. Cell cycle analysis revealed that the SCP 1 induced apoptosis in T-47D breast cancer cell line. Moreover, in vivo, the SCP 1 showed tumor growth inhibition in rat model that developed mammary carcinoma by 44.8% compared to the vehicle treated control. Thus, the SCP 1 exhibits specific in vivo and in vitro antitumor effects. The reaction of Me3SnCl, K3[Ag(CN)4] and 1,2-bis(4-pyridyl)ethane (bpe) in water/CH3CN solution at room temperature affords the novel bimetallic supramolecular coordination polymer (SCP) {[SnMe3(bpe)][Ag(CN)2]·2H2O}, SCP 1, which exhibits specific in vivo and in vitro antitumor effects. [Display omitted] ▸ The reaction of Me3SnCl, K3[Ag(CN)4] and 1,2-bis(4-pyridyl)ethane. ▸ Bimetallic supramolecular coordination polymer (SCP) {[SnMe3(bpe)][Ag(CN)2]·2H2O}, 1. ▸ 3D-supramolecular structure through hydrogen bonds. ▸ SCP 1 exhibits strong fluorescence in the solid state at room temperature. ▸ SCP 1 exhibits specific in vivo and in vitro antitumor effects.