Rabies Virus Neutralizing Activity, Safety, and Immunogenicity of Recombinant Human Rabies Antibody Compared with Human Rabies Immunoglobulin in Healthy Adults

• Published in: Biomedical and environmental sciences Vol. 35; no. 9; pp. 782 - 791
• Main Authors: ZHANG, Jun Nan, MENG, Ya Juan, BAI, Yun Hua, LI, Yu Feng, YANG, Li Qing, SHI, Nian Min, HAN, Hui Xia, GAO, Jian, ZHU, Li Juan, LI, Shu Ping, ZHANG, Jing, ZHAO, Qin Hua, WANG, Xiu Qin, WEI, Jing Shuang, REN, Le Min, CAO, Chen Hua, CHEN, Chen, ZHAO, Wei, LI, Li
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 20.09.2022; Center for Disease Control and Prevention of Chaoyang District,Beijing 100021,China%NCPC New Drug Research and Development Co.,Ltd.,State Key Laboratory of Antibody Research&Development,Shijiazhuang 050015,Hebei,China%Beijing Institute of Biological Products,Beijing 100021,China%Xiaohongmen Community Healthcare Center,Beijing 100023,China
• Subjects: Human rabies immunoglobulin; Immunogenicity; NM57; Rabies virus neutralizing activity; Recombinant human rabies antibody; Safety; Recombinant human rabies antibody; Human rabies immunoglobulin; Safety; Rabies virus neutralizing activity; Immunogenicity; NM57

Preliminary assessment of rabies virus neutralizing activity, safety and immunogenicity of a recombinant human rabies antibody (NM57) compared with human rabies immunoglobulin (HRIG) in Chinese healthy adults. Subjects were randomly (1:1:1) allocated to Groups A (20 IU/kg NM57), B (40 IU/kg NM57), o...