Thermodynamics of solutions: II. Flurbiprofen and diflunisal as models for studying solvation of drug substances

• Published in: European journal of pharmaceutical sciences Vol. 19; no. 5; pp. 423 - 432
• Main Authors: Perlovich, German L., Kurkov, Sergey V., Bauer-Brandl, Annette
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2003
• Subjects: Alcohols - chemistry; Algorithms; Calorimetry, Differential Scanning; Compensation effect; Diflunisal; Diflunisal - chemistry; Entropy; Flurbiprofen; Flurbiprofen - chemistry; Organic solvents; Pharmaceutical Solutions - chemistry; Regression Analysis; Solubility; Solvation; Solvents; Sublimation; Thermodynamics; Solvation; Compensation effect; Organic solvents; Sublimation; Solubility; Diflunisal; Flurbiprofen

Three independent methods (sublimation, solubility and solution calorimetry) were used to study the dissolution and solvation processes of diflunisal (DIF) and flurbiprofen (FBP). Thermodynamic functions for the sublimation of DIF and FBP were obtained. Concentrations of saturated solutions and stan...