Role of prostanoid EP3/1 receptors in mechanisms of emesis and defaecation in ferrets

• Published in: European journal of pharmacology Vol. 803; pp. 112 - 117
• Main Authors: Kan, Kelvin K.W., Wai, Man K., Jones, Robert L., Rudd, John A.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.05.2017
• Subjects: Defaecation; Emesis; Ferret; Prostanoid; Sulprostone; Tachykinin; Defaecation; Tachykinin; Ferret; Sulprostone; Emesis; Prostanoid

Prostanoid EP receptor agonists are used for a number of clinical indications but may be associated with gastric disturbance. In the present studies we used the ferret and sulprostone (30µg/kg, i.p.) to investigate the role of EP3/1 receptors in mechanisms of emesis and defaecation. The emetic respo...