Synthesis of anticonvulsive AMPA antagonists: 4-Oxo-10-substituted-imidazo[1,2- a]indeno[1,2- e]pyrazin-2-carboxylic acid derivatives

• Published in: Bioorganic & medicinal chemistry letters Vol. 11; no. 9; pp. 1205 - 1210
• Main Authors: Stutzmann, Jean-Marie, Bohme, Georg Andrees, Boireau, Alain, Damour, Dominique, Debono, Marc Williams, Genevois-Borella, Arielle, Jimonet, Patrick, Pratt, Jeremy, Randle, John C.R, Ribeill, Yves, Vuilhorgne, Marc, Mignani, Serge
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 07.05.2001; Elsevier
• Subjects: Anticonvulsants. Antiepileptics. Antiparkinson agents; Biological and medical sciences; Medical sciences; Neuropharmacology; Pharmacology. Drug treatments; Intraperitoneal administration; Intravenous administration; Rat; Angular nitrogen heterocycle; Central nervous system; Lactam; Anticonvulsant; Glutamate receptor; Structure activity relation; Aromatic compound; Antagonist; Chemical synthesis; Neurological disorder; Rodentia; Tetracyclic compound; In vitro; Vertebrata; Chemotherapy; Experimental disease; AMPA receptor; Mammalia; Treatment; Convulsion; Mouse; Animal; Affinity; Brain (vertebrata)

The overstimulation of excitatory amino acid receptors such as the glutamate AMPA receptor has been implicated in the physiopathogenesis of epilepsy as well as in acute and chronic neurodegenerative disorders. An original series of readily water soluble 4-oxo-10-substituted-imidazo[1,2- a]indeno[1,2...