Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicle Infusion for the Treatment of Respiratory Failure From COVID-19

• Published in: Chest Vol. 164; no. 6; pp. 1444 - 1453
• Main Authors: Lightner, Amy L., Sengupta, Vikram, Qian, Sascha, Ransom, John T., Suzuki, Sam, Park, David J., Melson, Timothy I., Williams, Brian P., Walsh, James J., Awili, Mustafa
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.12.2023
• Subjects: bone marrow mesenchymal stem cell; COVID-19; efficacy; extracellular vesicle; safety; AE; ITT; BM-MSC; bone marrow mesenchymal stem cell; efficacy; ExoFlo-15; COVID-19; EV; TEAE; ExoFlo-10; VFD; safety; SAE; IRB; extracellular vesicle

Bone marrow mesenchymal stem cell (BM-MSC)-derived extracellular vesicles (ExoFlo) convey the immunomodulatory and regenerative properties of intact BM-MSCs. This study aimed to determine the safety and efficacy of ExoFlo as treatment for moderate to severe ARDS in patients with severe COVID-19. Do...