A novel phosphodiesterase 1 inhibitor reverses L-dopa-induced dyskinesia, but not motivation deficits, in monkeys

• Published in: Pharmacology, biochemistry and behavior Vol. 205; p. 173183
• Main Authors: Enomoto, Takeshi, Nakako, Tomokazu, Goda, Masao, Wada, Erika, Kitamura, Atsushi, Fujii, Yuki, Ikeda, Kazuhito
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2021
• Subjects: L-Dopa-induced dyskinesia; Motivational deficits; Parkinsonian macaque model; Phosphodiesterase 1; PDE1; Phosphodiesterase 1; Parkinsonian macaque model; cGMP; cAMP; L-Dopa-induced dyskinesia; PDE; DSR-141562; ITI-214; DSR-143136; L-Dopa; IMAP FP assay; Motivational deficits; MPTP

The enzyme phosphodiesterase 1 (PDE1) is highly expressed in the striatum and cortex. However, its role in corticostriatal function has not been fully investigated. The present study was aimed at evaluating the therapeutic potential of PDE1 inhibitors in treating motivation deficits and 3,4-dihydrox...