Effects of betanin on AMPK, Sirtuin1, and Sirtuin6 gene expression and inflammatory cytokines levels in peripheral blood mononuclear cells of patients with coronary artery disease

• Published in: Nutrition and food science Vol. 52; no. 5; pp. 843 - 857
• Main Authors: Mahami, Neda, Abedimanesh, Nasim, Asghari, Somayyeh, Mohammadnejad, Kosar, Eskandari, Mohammad Reza, Nejadebrahimi, Zivar, Ahangar, Hassan, Nedaei, Keivan, Fathi, Mojtaba, Noori, Ehsan, Motlagh, Behrooz
• Format: Journal Article
• Language: English
• Published: Bradford Emerald Publishing Limited 28.06.2022; Emerald Group Publishing Limited
• Subjects: AMP-activated protein kinase; Atherosclerosis; Blood; Cardiovascular disease; Cell culture; Coronary artery; Coronary artery disease; Coronary vessels; Cytokines; Disease control; Gene expression; Heart diseases; Inflammation; Interleukin 6; Kinases; Leukocytes (mononuclear); Oxidative stress; Patients; Penicillin; Peripheral blood mononuclear cells; Polymerase chain reaction; Proteins; Reagents; SIRT1 protein; Software; Tumor necrosis factor-α; Tumors; Vein & artery diseases; Iran; United States > US; Germany; AMPK; TNF-α; Sirtuin 1; Coronary artery disease; Betanin; Sirtuin 6

Purpose This study aims to evaluate the effects of betanin on AMP-activated protein kinase (AMPK), Sirtuin1 (SIRT1) and Sirtuin6 (SIRT6) gene expression as well as the tumour necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) cytokine release in peripheral blood mononuclear cells (PBMCs) of pati...