A randomized trial comparing 35 Gy in ten fractions with 60 Gy in 30 fractions of cerebral irradiation for glioblastoma multiforme and older patients with anaplastic astrocytoma

A randomized prospective clinical trial was conducted to compare conventional high dose radiotherapy with hypofractionated, short course radiotherapy in poor prognosis patients with high grade glioma. The primary endpoint was overall survival.

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Published inRadiotherapy and oncology Vol. 68; no. 1; pp. 23 - 26
Main Authors Phillips, Claire, Guiney, Michael, Smith, Jennifer, Hughes, Peter, Narayan, Kailash, Quong, George
Format Journal Article
LanguageEnglish
Published Elsevier Ireland Ltd 2003
Subjects
Anaplastic astrocytoma
Glioblastoma multiforme
Palliation
Radiotherapy
Survival
Radiotherapy
Glioblastoma multiforme
Survival
Palliation
Anaplastic astrocytoma
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Abstract A randomized prospective clinical trial was conducted to compare conventional high dose radiotherapy with hypofractionated, short course radiotherapy in poor prognosis patients with high grade glioma. The primary endpoint was overall survival.
AbstractList A randomized prospective clinical trial was conducted to compare conventional high dose radiotherapy with hypofractionated, short course radiotherapy in poor prognosis patients with high grade glioma. The primary endpoint was overall survival.
Author Guiney, Michael
Smith, Jennifer
Narayan, Kailash
Quong, George
Hughes, Peter
Phillips, Claire
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Keywords Radiotherapy
Glioblastoma multiforme
Survival
Palliation
Anaplastic astrocytoma
Language English
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References Bauman, Gaspar, Fisher, Halperin, Macdonald, Cairncross (BIB2) 1994; 29
Newall, Ransohoff, Kaplan (BIB15) 1988; 6
Bottomley, Vanvoorden, Flechtner, Therasse (BIB4) 2003; 39
(BIB18) 2001
Genc, Zorlu, Atahan (BIB9) 2000; 56
Walker, Eben, Hunt (BIB23) 1978; 49
Kristiansen, Hagen, Kollevold (BIB13) 1981; 47
Walker, Strike, Sheline (BIB24) 1979; 5
Jansen, Dewit, Edwin (BIB11) 2000; 56
Curran, Scott, Horton (BIB6) 1993; 85
Andersen (BIB1) 1978; 17
(BIB19) 1995
Hulshof, Schimmel, Bosch, Gonzales (BIB10) 2000; 54
Nelson, Diener-West, Horton (BIB14) 1988; 6
Bleehan, Stenning (BIB3) 1991; 64
Videtic, Gaspar, Zamorano (BIB22) 2001; 5
Thomas, James, Guerrero, Ashley, Gregor, Brada (BIB21) 1994; 33
Slotman, Kralendonk, van Alphen, Kamphorst, Karim (BIB16) 1996; 34
Ford, Stenning, Boote (BIB8) 1997; 9
(BIB17) 1999
Kleinberg, Slick, Enger, Grossman, Brem, Wharam (BIB12) 1997; 38
Tamura, Nakamure, Kunimine (BIB20) 1989; 7
Efficace, Bottomley (BIB7) 2002; 38
Chan, Lee, Fraass (BIB5) 2002; 20
References_xml – volume: 33
  start-page: 113
  year: 1994
  end-page: 116
  ident: BIB21
  article-title: Hypofractionated radiotherapy as palliative treatment in poor prognosis patients with high grade glioma
  publication-title: Radiother Oncol
  contributor:
    fullname: Brada
– volume: 6
  start-page: 279
  year: 1988
  end-page: 284
  ident: BIB14
  article-title: Combined modality approach to treatment of malignant gliomas – re-evaluation of RTOG 7401/ECOG 1374 with long-term follow-up: a joint study of the Radiation Therapy Oncology Group and the Eastern Cooperative Oncology Group
  publication-title: NCI Monogr
  contributor:
    fullname: Horton
– volume: 34
  start-page: 895
  year: 1996
  end-page: 898
  ident: BIB16
  article-title: Hypofractionated radiation therapy in patients with glioblastoma multiforme: results of treatment and impact of prognostic factors
  publication-title: Int J Radiat Oncol Biol Phys
  contributor:
    fullname: Karim
– volume: 38
  start-page: 1824
  year: 2002
  end-page: 1831
  ident: BIB7
  article-title: Health related quality of life assessment methodology and reported outcomes in randomised controlled trials of primary brain cancer patients
  publication-title: Eur J Cancer
  contributor:
    fullname: Bottomley
– volume: 38
  start-page: 31
  year: 1997
  end-page: 36
  ident: BIB12
  article-title: Short course radiotherapy is an appropriate option for most malignant glioma patients
  publication-title: Int J Radiat Oncol Biol Phys
  contributor:
    fullname: Wharam
– volume: 7
  start-page: 113
  year: 1989
  end-page: 119
  ident: BIB20
  article-title: Large dose fraction radiotherapy in the treatment of glioblastoma
  publication-title: J Neurooncol
  contributor:
    fullname: Kunimine
– volume: 5
  start-page: 963
  year: 2001
  end-page: 968
  ident: BIB22
  article-title: Implant volume as a prognostic variable in brachytherapy decision-making for malignant gliomas stratified by the RTOG recursive partitioning analysis
  publication-title: Int J Radiat Oncol Biol Phys
  contributor:
    fullname: Zamorano
– volume: 39
  start-page: 275
  year: 2003
  end-page: 285
  ident: BIB4
  article-title: The challenges and achievements involved in implementing quality of life research in cancer clinical trials
  publication-title: Eur J Cancer
  contributor:
    fullname: Therasse
– volume: 29
  start-page: 835
  year: 1994
  end-page: 839
  ident: BIB2
  article-title: A prospective study of short-course radiotherapy in poor prognosis glioblastoma multiforme
  publication-title: Int J Radiat Oncol Biol Phys
  contributor:
    fullname: Cairncross
– volume: 6
  start-page: 325
  year: 1988
  end-page: 327
  ident: BIB15
  article-title: Glioblastoma in the older patient: how long a course of radiotherapy is necessary?
  publication-title: J Neurooncol
  contributor:
    fullname: Kaplan
– volume: 5
  start-page: 1725
  year: 1979
  end-page: 1731
  ident: BIB24
  article-title: An analysis of dose-effect relationship in the radiotherapy of malignant gliomas
  publication-title: Int J Radiat Oncol Biol Phys
  contributor:
    fullname: Sheline
– volume: 64
  start-page: 769
  year: 1991
  end-page: 774
  ident: BIB3
  article-title: A Medical Research Council trial of two radiotherapy doses in the treatment of grades 3 and 4 astrocytoma
  publication-title: Br J Cancer
  contributor:
    fullname: Stenning
– year: 2001
  ident: BIB18
  publication-title: SPSS Advanced Statistics 11.0.1
– year: 1995
  ident: BIB19
  publication-title: StatXact 3.0.2
– volume: 20
  start-page: 1635
  year: 2002
  end-page: 1642
  ident: BIB5
  article-title: Survival and failure of high-grade gliomas after three dimensional conformal radiotherapy
  publication-title: J Clin Oncol
  contributor:
    fullname: Fraass
– volume: 56
  start-page: 151
  year: 2000
  end-page: 156
  ident: BIB11
  article-title: Target volumes in radiotherapy for high-grade malignant gliomas of the brain
  publication-title: Radiother Oncol
  contributor:
    fullname: Edwin
– volume: 9
  start-page: 20
  year: 1997
  end-page: 24
  ident: BIB8
  article-title: A short fractionation radiotherapy treatment for poor prognosis patients with high grade glioma
  publication-title: Clin Oncol
  contributor:
    fullname: Boote
– volume: 85
  start-page: 704
  year: 1993
  end-page: 710
  ident: BIB6
  article-title: Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials
  publication-title: J Natl Cancer Inst
  contributor:
    fullname: Horton
– volume: 56
  start-page: 233
  year: 2000
  end-page: 238
  ident: BIB9
  article-title: Accelerated hyperfractionated radiotherapy in supratentorial malignant astrocytomas
  publication-title: Radiother Oncol
  contributor:
    fullname: Atahan
– volume: 49
  start-page: 333
  year: 1978
  end-page: 343
  ident: BIB23
  article-title: Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas
  publication-title: J Neurosurg
  contributor:
    fullname: Hunt
– volume: 17
  start-page: 475
  year: 1978
  end-page: 484
  ident: BIB1
  article-title: Post-operative irradiation of glioblastomas
  publication-title: Acta Radiol Oncol
  contributor:
    fullname: Andersen
– volume: 54
  start-page: 143
  year: 2000
  end-page: 148
  ident: BIB10
  article-title: Hypofractionation in glioblastoma multiforme
  publication-title: Radiother Oncol
  contributor:
    fullname: Gonzales
– volume: 47
  start-page: 649
  year: 1981
  end-page: 652
  ident: BIB13
  article-title: Combined modality therapy of operated astrocytomas grade III and IV. Confirmation of the value of post-operative irradiation and lack of potentiation of bleomycin on survival time
  publication-title: Cancer
  contributor:
    fullname: Kollevold
– year: 1999
  ident: BIB17
  publication-title: S-plus 2000
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Snippet A randomized prospective clinical trial was conducted to compare conventional high dose radiotherapy with hypofractionated, short course radiotherapy in poor...
SourceID elsevier
SourceType Publisher
StartPage 23
SubjectTerms Anaplastic astrocytoma
Glioblastoma multiforme
Palliation
Radiotherapy
Survival
Title A randomized trial comparing 35 Gy in ten fractions with 60 Gy in 30 fractions of cerebral irradiation for glioblastoma multiforme and older patients with anaplastic astrocytoma
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Volume 68
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