Role of the M 1 receptor in regulating circadian rhythms

• Published in: Life sciences (1973) Vol. 68; no. 22; pp. 2467 - 2472
• Main Authors: Gillette, Martha U., Buchanan, Gordon F., Artinian, Liana, Hamilton, Susan E., Nathanson, Neil M., Liu, Chen
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 27.04.2001
• Subjects: Acetylcholine; cGMP/PKG signaling; Circadian rhythms; Muscarinic receptors; Suprachiasmatic nucleus; Circadian rhythms; Suprachiasmatic nucleus; Acetylcholine; cGMP/PKG signaling; Muscarinic receptors

Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacol...