Role of the M 1 receptor in regulating circadian rhythms

Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacol...

Full description

Saved in:
Bibliographic Details
Published inLife sciences (1973) Vol. 68; no. 22; pp. 2467 - 2472
Main Authors Gillette, Martha U., Buchanan, Gordon F., Artinian, Liana, Hamilton, Susan E., Nathanson, Neil M., Liu, Chen
Format Journal Article
LanguageEnglish
Published Elsevier Inc 27.04.2001
Subjects
Acetylcholine
cGMP/PKG signaling
Circadian rhythms
Muscarinic receptors
Suprachiasmatic nucleus
Circadian rhythms
Suprachiasmatic nucleus
Acetylcholine
cGMP/PKG signaling
Muscarinic receptors
Online AccessGet full text

Cover

More Information
Summary:Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M 1–like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(01)01040-2