Neurocrest and colonic tumors: New clinical syndrome: Report of three cases

• Published in: The American journal of medicine Vol. 77; no. 4; pp. 725 - 728
• Main Authors: Wade, James L., Tobin, Ellis, Ultmann, John E.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.1984; Elsevier
• Subjects: Adenoma - embryology; Adrenal Gland Neoplasms - embryology; Adult; Biological and medical sciences; Carcinoid Tumor - embryology; Carcinoid Tumor - secondary; Carcinoma - embryology; Carcinoma - secondary; Colonic Neoplasms - embryology; Endoderm; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Intestinal Polyps - embryology; Liver Neoplasms - secondary; Lung Neoplasms - secondary; Male; Medical sciences; Middle Aged; Neoplasms, Multiple Primary - embryology; Neural Crest; Pheochromocytoma - embryology; Pheochromocytoma - secondary; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Syndrome; Thyroid Neoplasms - embryology; Tumors; Endocrinopathy; Human; Multiple; Pheochromocytoma; Adrenal medulla; Hereditary; Polyposis; Pathology; Concomitant disease; Digestive diseases; Intestinal disease; Tumor; Colon
• ISSN: 0002-9343; 1555-7162
• DOI: 10.1016/0002-9343(84)90373-5

This report describes three patients with both multiple intestinal polyps and tumors of neural crest origin. This combination of findings may represent a new clinical syndrome. The embryologic relationships between tumors derived from endoderm and tumors derived from neurocrest are described. An inherent defect in tissue proliferation or repair is postulated to explain the abnormal growth in these two different cell lines.