Expression of BLT1 leukotriene B 4 receptor on the dorsal root ganglion neurons in mice

We investigated using mice whether dorsal root ganglion (DRG) neurons express leukotriene B 4 receptors. BLT1, but not BLT2, receptor mRNA was expressed in the DRG. Leukotriene B 4 increased intracellular Ca 2+ concentration in cultured DRG neurons, which was inhibited by leukotriene B 4 antagonist....

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Bibliographic Details
Published inBrain research. Molecular brain research. Vol. 137; no. 1; pp. 263 - 266
Main Authors Andoh, Tsugunobu, Kuraishi, Yasushi
Format Journal Article
LanguageEnglish
Published Elsevier B.V 2005
Subjects
BLT1 receptor
Dorsal root ganglion neuron
Intracellular Ca 2
Leukotriene B 4
Dorsal root ganglion neuron
Leukotriene B 4
Intracellular Ca 2
Neurotransmitters, modulators, transporters, and receptors
BLT1 receptor
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ISSN0169-328X
1872-6941
DOI10.1016/j.molbrainres.2005.02.029

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Summary:We investigated using mice whether dorsal root ganglion (DRG) neurons express leukotriene B 4 receptors. BLT1, but not BLT2, receptor mRNA was expressed in the DRG. Leukotriene B 4 increased intracellular Ca 2+ concentration in cultured DRG neurons, which was inhibited by leukotriene B 4 antagonist. Many BLT1-immunoreactive neurons were small in size and positive for TRPV1. BLT1-immunoreactive fibers are present in the skin. The results suggest the expression of functional BLT1 receptors in the sensory neurons.
ISSN:0169-328X
1872-6941
DOI:10.1016/j.molbrainres.2005.02.029