Deamination of the microbial toxin trans L ¯ ¯ ‐2‐AMINO‐4‐METHOXY‐3‐BUTENOIC acid and its parent vinylglycine by sheep liver serine-threonine dehydratase

The microbial toxin trans L ¯ ¯ ‐2‐amino‐4‐methoxy‐3‐butenoic acid and its parent vinylglycine are deaminated to alpha ketoacids by sheep liver serine threonine dehydratase. The ability of the dehydratase to deaminate the above compounds is consistent with the proposed mechanism for dehydratases. Si...

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Published inBiochemical and biophysical research communications Vol. 65; no. 2; pp. 765 - 769
Main Authors Kapke, Gordon, Davis, Leodis
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 22.07.1975
Subjects
Alkenes
Aminobutyrates
Animals
Glycine
Kinetics
L-Serine Dehydratase - metabolism
Liver - enzymology
Sheep
Toxins, Biological
Vinyl Compounds
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Abstract The microbial toxin trans L ¯ ¯ ‐2‐amino‐4‐methoxy‐3‐butenoic acid and its parent vinylglycine are deaminated to alpha ketoacids by sheep liver serine threonine dehydratase. The ability of the dehydratase to deaminate the above compounds is consistent with the proposed mechanism for dehydratases. Since these compounds irreversibly inhibit pig heart aspartate aminotransferase (1), the dehydratase may act as a detoxification pathway.
AbstractList The microbial toxin trans L ¯ ¯ ‐2‐amino‐4‐methoxy‐3‐butenoic acid and its parent vinylglycine are deaminated to alpha ketoacids by sheep liver serine threonine dehydratase. The ability of the dehydratase to deaminate the above compounds is consistent with the proposed mechanism for dehydratases. Since these compounds irreversibly inhibit pig heart aspartate aminotransferase (1), the dehydratase may act as a detoxification pathway.
Author Davis, Leodis
Kapke, Gordon
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References Rando (bib1) 1974; 13
Davis (bib4) 1965; 12
Kapke (bib5) 1975
Kapke, G., and Davis, L. Biochemistry (In Press).
Dardenne, Casimir, Marlier, Larsen (bib2) 1974; 13
Dixon, Davis (bib6) 1967; 119
References_xml – year: 1975
  ident: bib5
  publication-title: Ph.D. Thesis
  contributor:
    fullname: Kapke
– volume: 13
  start-page: 3859
  year: 1974
  ident: bib1
  publication-title: Biochemistry
  contributor:
    fullname: Rando
– volume: 13
  start-page: 1897
  year: 1974
  ident: bib2
  publication-title: Phytochemistry
  contributor:
    fullname: Larsen
– volume: 12
  start-page: 36
  year: 1965
  ident: bib4
  publication-title: Anal. Biochem.
  contributor:
    fullname: Davis
– volume: 119
  start-page: 155
  year: 1967
  ident: bib6
  publication-title: Arch. of Biochem. and Biophys.
  contributor:
    fullname: Davis
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Snippet The microbial toxin trans L ¯ ¯ ‐2‐amino‐4‐methoxy‐3‐butenoic acid and its parent vinylglycine are deaminated to alpha ketoacids by sheep liver serine...
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SubjectTerms Alkenes
Aminobutyrates
Animals
Glycine
Kinetics
L-Serine Dehydratase - metabolism
Liver - enzymology
Sheep
Toxins, Biological
Vinyl Compounds
Title Deamination of the microbial toxin trans L ¯ ¯ ‐2‐AMINO‐4‐METHOXY‐3‐BUTENOIC acid and its parent vinylglycine by sheep liver serine-threonine dehydratase
URI https://dx.doi.org/10.1016/S0006-291X(75)80211-7
https://www.ncbi.nlm.nih.gov/pubmed/1148013
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Volume 65
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