Deamination of the microbial toxin trans L ¯ ¯ ‐2‐AMINO‐4‐METHOXY‐3‐BUTENOIC acid and its parent vinylglycine by sheep liver serine-threonine dehydratase
The microbial toxin trans L ¯ ¯ ‐2‐amino‐4‐methoxy‐3‐butenoic acid and its parent vinylglycine are deaminated to alpha ketoacids by sheep liver serine threonine dehydratase. The ability of the dehydratase to deaminate the above compounds is consistent with the proposed mechanism for dehydratases. Si...
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Published in | Biochemical and biophysical research communications Vol. 65; no. 2; pp. 765 - 769 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
22.07.1975
|
Subjects | |
Online Access | Get full text |
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Abstract | The microbial toxin
trans
L
¯
¯
‐2‐amino‐4‐methoxy‐3‐butenoic
acid and its parent vinylglycine are deaminated to alpha ketoacids by sheep liver serine threonine dehydratase. The ability of the dehydratase to deaminate the above compounds is consistent with the proposed mechanism for dehydratases. Since these compounds irreversibly inhibit pig heart aspartate aminotransferase (1), the dehydratase may act as a detoxification pathway. |
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AbstractList | The microbial toxin
trans
L
¯
¯
‐2‐amino‐4‐methoxy‐3‐butenoic
acid and its parent vinylglycine are deaminated to alpha ketoacids by sheep liver serine threonine dehydratase. The ability of the dehydratase to deaminate the above compounds is consistent with the proposed mechanism for dehydratases. Since these compounds irreversibly inhibit pig heart aspartate aminotransferase (1), the dehydratase may act as a detoxification pathway. |
Author | Davis, Leodis Kapke, Gordon |
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References | Rando (bib1) 1974; 13 Davis (bib4) 1965; 12 Kapke (bib5) 1975 Kapke, G., and Davis, L. Biochemistry (In Press). Dardenne, Casimir, Marlier, Larsen (bib2) 1974; 13 Dixon, Davis (bib6) 1967; 119 |
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Snippet | The microbial toxin
trans
L
¯
¯
‐2‐amino‐4‐methoxy‐3‐butenoic
acid and its parent vinylglycine are deaminated to alpha ketoacids by sheep liver serine... |
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StartPage | 765 |
SubjectTerms | Alkenes Aminobutyrates Animals Glycine Kinetics L-Serine Dehydratase - metabolism Liver - enzymology Sheep Toxins, Biological Vinyl Compounds |
Title | Deamination of the microbial toxin trans L ¯ ¯ ‐2‐AMINO‐4‐METHOXY‐3‐BUTENOIC acid and its parent vinylglycine by sheep liver serine-threonine dehydratase |
URI | https://dx.doi.org/10.1016/S0006-291X(75)80211-7 https://www.ncbi.nlm.nih.gov/pubmed/1148013 https://search.proquest.com/docview/82956123 |
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