Chapter 9. Synthetic probes for polyketide and nonribosomal peptide biosynthetic enzymes

• Published in: Methods in enzymology Vol. 458; p. 219
• Main Authors: Meier, Jordan L, Burkart, Michael D
• Format: Journal Article
• Language: English
• Published: United States 2009
• Subjects: Molecular Probes - chemical synthesis; Molecular Probes - chemistry; Molecular Probes - metabolism; Molecular Structure; Peptide Synthases - chemistry; Peptide Synthases - metabolism; Polyketide Synthases - chemistry; Polyketide Synthases - metabolism; Protein Binding - genetics; Protein Binding - physiology; Protein Structure, Secondary

Polyketides and nonribosomal peptides constitute two classes of small molecule natural products that are well-known for their ability to impact important biological processes in a multitude of ways. The modular biosynthetic enzymes responsible for production of these compounds (PKS and NRPS enzymes)...