Crystal Structure of a Bulged RNA Tetraplex at 1.1 Å Resolution: Implications for a Novel Binding Site in RNA Tetraplex

• Published in: Structure (London) Vol. 11; no. 11; pp. 1423 - 1430
• Main Authors: Pan, Baocheng, Xiong, Yong, Shi, Ke, Sundaralingam, Muttaiya
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2003
• Subjects: Binding Sites; Crystallography, X-Ray; Guanine - chemistry; Hydrogen Bonding; Ions; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Conformation; Protein Conformation; RNA - chemistry; Saccharomyces cerevisiae - metabolism; Software; Uridine - chemistry; Water - chemistry

Bulges are an important structural motif in RNA and can be used as recognition and interaction sites in RNA-protein interaction and RNA-RNA interaction. Here we report the first crystal structure of a bulged RNA tetraplex at 1.1 Å resolution. The hexamer r(U)( BrdG)r(UGGU) forms a parallel tetraplex...