In-depth characterization of CD24highCD38high transitional human B cells reveals different regulatory profiles

• Published in: Journal of allergy and clinical immunology Vol. 137; no. 5; pp. 1577 - 1584.e10
• Main Authors: Simon, Quentin, Pers, Jacques-Olivier, Cornec, Divi, Le Pottier, Laëtitia, Mageed, Rizgar A., Hillion, Sophie
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.05.2016; Elsevier
• Subjects: autoimmunity; chronic inflammatory diseases; immune regulation; Immunology; Life Sciences; Transitional B cells; chronic inflammatory diseases; MNC; PC5; KO; Breg; PLCγ2; SLE; Transitional B cells; immune regulation; FLOCK; BCR; MFI; pSS; FITC; PB; SPADE; autoimmunity; APC; PE; HC; T1; T2; T3

CD24highCD38high transitional B cells represent cells at a key stage in their developmental pathway. In addition, these B cells have been widely ascribed regulatory functions and involvement in the control of chronic inflammatory diseases. However, the phenotypic and functional overlap between these...