Synthesis of homochiral syn- and anti-α-(hydroxyethyl)-γ-butyrolactones via microbial reduction

Various yeast and mould suains were tested in the reduction of (α-acetyl-γ-butyrolactone. syn-(3R,1′R)-α(-(Hydroxyethyl)-γ-butyrolactone 2 and anti-(3R,1′S) isomer 3 were obtained enantiomerically pure. Good enantiomeric excesses are described for the corresponding enantiomers. syn- and anti-α-(Hydr...

Full description

Saved in:
Bibliographic Details
Published inTetrahedron: asymmetry Vol. 5; no. 9; pp. 1631 - 1634
Main Authors Fantin, Giancarlo, Fogagnolo, Marco, Giovannini, Paolo, Medici, Alessandro, Pagnotta, Edoardo, Pedrini, Paola, Trincone, Antonio
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.09.1994
Elsevier Science
Subjects
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Chemistry
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Heterocyclic compounds
Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives
Methods. Procedures. Technologies
Organic chemistry
Preparations and properties
Chemical reduction
Stereoselectivity
Five membered ring
Enantioselectivity
Enantiomeric excess
Lactone
Secondary alcohol
Oxygen heterocycle
Ketone
Enzymatic reaction
Online AccessGet full text

Cover

More Information
Summary:Various yeast and mould suains were tested in the reduction of (α-acetyl-γ-butyrolactone. syn-(3R,1′R)-α(-(Hydroxyethyl)-γ-butyrolactone 2 and anti-(3R,1′S) isomer 3 were obtained enantiomerically pure. Good enantiomeric excesses are described for the corresponding enantiomers. syn- and anti-α-(Hydroxyethyl)-γ-butyrolactones enantiomerically pure are obtained via microbial reduction.
ISSN:0957-4166
1362-511X
DOI:10.1016/0957-4166(94)80067-7