Wound healing potential of Vakeri fortified KampillakadiTaila
Traditional medicine in form of decoctions has been known for ages to possess wound healing abilities. One such traditional formulation mentioned in Indian literature Charak Samhita Chikitsa Sthanam is Kampillakadi Taila and tremendous information is available on its implication in the treatment of...
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Published in | Journal of ayurveda and integrative medicine Vol. 14; no. 3; p. 100721 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.05.2023
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Abstract | Traditional medicine in form of decoctions has been known for ages to possess wound healing abilities. One such traditional formulation mentioned in Indian literature Charak Samhita Chikitsa Sthanam is Kampillakadi Taila and tremendous information is available on its implication in the treatment of skin cuts and wounds, diseases, or bacterial infections. This research paper focuses on studying the wound healing property of one such herbal proprietary formulation known as a wound healing oil, derived from Kampillakadi Taila fortified with root extract of Wagatea spicata (VIKHPF).
The current research is aimed at studying chemical profiling, antioxidant activity, antimicrobial efficacy, in-vitro cell proliferating, and in-vitro wound healing activity of this VKHPF.
The chemical characterization of VKHPF was done by gas chromatography- fatty acid methyl esters GC-FAME analysis for lipid analysis and gas chromatography high-resolution mass spectrometry (GC-HRMS)for revealing its chemical constituents. Proliferation and migration are two underlying mechanisms involved in the healing of wounds. Hence, in-vitro studies such as cell proliferation assay and in-vitro scratch test on NIH/3T3 mice fibroblast cell line were conducted were used to determine in-vitro wound healing capacity of VKHPF. The oil was also tested for antioxidant effect (DPPH assay) and anti-microbial potential (Time kill test).
The GC-HRMS and GC-FAME analyses revealed rich medicinally important fatty acids and vitamins were present in VKHPF, such as oleic acid, hexadecanoic acid, squalene, α, γ-tocopherol, γ-sitosterol, and benzoic acid. VKHPF at 0.5 mg/ml in media without serum showed 164.00 ± 0.011% cell viability with 64.00% cell proliferation in contrast to media containing serum (100% cell viability). At the same concentration, the wound closure was 98% for VKHPF. The oil sample possessed antioxidant activity with an IC50 value of 3.5 mg/ml and antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa when tested using Time Kill Activity.
This study is the first to report the use of Vakeri fortified Kampillakadi Taila herbal proprietary formulation (VKHPF) in in-vitro wound healing and the present data suggest that it can form a part of modern medicine.
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AbstractList | Traditional medicine in form of decoctions has been known for ages to possess wound healing abilities. One such traditional formulation mentioned in Indian literature Charak Samhita Chikitsa Sthanam is Kampillakadi Taila and tremendous information is available on its implication in the treatment of skin cuts and wounds, diseases, or bacterial infections. This research paper focuses on studying the wound healing property of one such herbal proprietary formulation known as a wound healing oil, derived from Kampillakadi Taila fortified with root extract of Wagatea spicata (VIKHPF).
The current research is aimed at studying chemical profiling, antioxidant activity, antimicrobial efficacy, in-vitro cell proliferating, and in-vitro wound healing activity of this VKHPF.
The chemical characterization of VKHPF was done by gas chromatography- fatty acid methyl esters GC-FAME analysis for lipid analysis and gas chromatography high-resolution mass spectrometry (GC-HRMS)for revealing its chemical constituents. Proliferation and migration are two underlying mechanisms involved in the healing of wounds. Hence, in-vitro studies such as cell proliferation assay and in-vitro scratch test on NIH/3T3 mice fibroblast cell line were conducted were used to determine in-vitro wound healing capacity of VKHPF. The oil was also tested for antioxidant effect (DPPH assay) and anti-microbial potential (Time kill test).
The GC-HRMS and GC-FAME analyses revealed rich medicinally important fatty acids and vitamins were present in VKHPF, such as oleic acid, hexadecanoic acid, squalene, α, γ-tocopherol, γ-sitosterol, and benzoic acid. VKHPF at 0.5 mg/ml in media without serum showed 164.00 ± 0.011% cell viability with 64.00% cell proliferation in contrast to media containing serum (100% cell viability). At the same concentration, the wound closure was 98% for VKHPF. The oil sample possessed antioxidant activity with an IC50 value of 3.5 mg/ml and antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa when tested using Time Kill Activity.
This study is the first to report the use of Vakeri fortified Kampillakadi Taila herbal proprietary formulation (VKHPF) in in-vitro wound healing and the present data suggest that it can form a part of modern medicine.
[Display omitted] Traditional medicine in form of decoctions has been known for ages to possess wound healing abilities. One such traditional formulation mentioned in Indian literature Charak Samhita Chikitsa Sthanam is Kampillakadi Taila and tremendous information is available on its implication in the treatment of skin cuts and wounds, diseases, or bacterial infections. This research paper focuses on studying the wound healing property of one such herbal proprietary formulation known as a wound healing oil, derived from Kampillakadi Taila fortified with root extract of Wagatea spicata (VIKHPF). The current research is aimed at studying chemical profiling, antioxidant activity, antimicrobial efficacy, in-vitro cell proliferating, and in-vitro wound healing activity of this VKHPF. The chemical characterization of VKHPF was done by gas chromatography- fatty acid methyl esters GC-FAME analysis for lipid analysis and gas chromatography high-resolution mass spectrometry (GC-HRMS)for revealing its chemical constituents. Proliferation and migration are two underlying mechanisms involved in the healing of wounds. Hence, in-vitro studies such as cell proliferation assay and in-vitro scratch test on NIH/3T3 mice fibroblast cell line were conducted were used to determine in-vitro wound healing capacity of VKHPF. The oil was also tested for antioxidant effect (DPPH assay) and anti-microbial potential (Time kill test). The GC-HRMS and GC-FAME analyses revealed rich medicinally important fatty acids and vitamins were present in VKHPF, such as oleic acid, hexadecanoic acid, squalene, α, γ-tocopherol, γ-sitosterol, and benzoic acid. VKHPF at 0.5 mg/ml in media without serum showed 164.00 ± 0.011% cell viability with 64.00% cell proliferation in contrast to media containing serum (100% cell viability). At the same concentration, the wound closure was 98% for VKHPF. The oil sample possessed antioxidant activity with an IC value of 3.5 mg/ml and antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa when tested using Time Kill Activity. This study is the first to report the use of Vakeri fortified Kampillakadi Taila herbal proprietary formulation (VKHPF) in in-vitro wound healing and the present data suggest that it can form a part of modern medicine. Image 1 BACKGROUNDTraditional medicine in form of decoctions has been known for ages to possess wound healing abilities. One such traditional formulation mentioned in Indian literature Charak Samhita Chikitsa Sthanam is Kampillakadi Taila and tremendous information is available on its implication in the treatment of skin cuts and wounds, diseases, or bacterial infections. This research paper focuses on studying the wound healing property of one such herbal proprietary formulation known as a wound healing oil, derived from Kampillakadi Taila fortified with root extract of Wagatea spicata (VIKHPF).OBJECTIVEThe current research is aimed at studying chemical profiling, antioxidant activity, antimicrobial efficacy, in-vitro cell proliferating, and in-vitro wound healing activity of this VKHPF.MATERIALS AND METHODSThe chemical characterization of VKHPF was done by gas chromatography- fatty acid methyl esters GC-FAME analysis for lipid analysis and gas chromatography high-resolution mass spectrometry (GC-HRMS)for revealing its chemical constituents. Proliferation and migration are two underlying mechanisms involved in the healing of wounds. Hence, in-vitro studies such as cell proliferation assay and in-vitro scratch test on NIH/3T3 mice fibroblast cell line were conducted were used to determine in-vitro wound healing capacity of VKHPF. The oil was also tested for antioxidant effect (DPPH assay) and anti-microbial potential (Time kill test).RESULTSThe GC-HRMS and GC-FAME analyses revealed rich medicinally important fatty acids and vitamins were present in VKHPF, such as oleic acid, hexadecanoic acid, squalene, α, γ-tocopherol, γ-sitosterol, and benzoic acid. VKHPF at 0.5 mg/ml in media without serum showed 164.00 ± 0.011% cell viability with 64.00% cell proliferation in contrast to media containing serum (100% cell viability). At the same concentration, the wound closure was 98% for VKHPF. The oil sample possessed antioxidant activity with an IC50 value of 3.5 mg/ml and antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa when tested using Time Kill Activity.CONCLUSIONThis study is the first to report the use of Vakeri fortified Kampillakadi Taila herbal proprietary formulation (VKHPF) in in-vitro wound healing and the present data suggest that it can form a part of modern medicine. |
ArticleNumber | 100721 |
Author | Khan, Rummana R. Gharpure, Milind Barve, Sidhivinayak S. Dhawal, Pranjali P. Joshi, Minal S. |
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Keywords | Antimicrobial Wound healing Scratch assay DPPH Kampillakadi Taila Vakeri |
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References | Witte, Barbul (bib8) 1997; 77 Saporito, Sandri, Bonferoni, Rossi, Boselli, Cornaglia (bib45) 2018; 13 Nandini, Vikas (bib43) 2020; 16 Edwards, Harding (bib13) 2004; 17 Chopda, Mahajan (bib19) 2009; 1 Nayak, Pandey, Swapna (bib37) 2016; 10 Dattatray, Kamini, Mohanlal (bib33) 2016; 7 Annan, Houghton (bib23) 2008; 119 Ramesh, Shivram (bib36) 2015; 4 Trombetta, Puglia, Perri, Licata, Pergolizzi, Lauriano (bib28) 2006; 13 Gangopadhyay, Khan, Pandit, Chakrabarti, Mondal, Biswas (bib20) 2014; 13 Shukla, Rasik, Jain, Shankar, Kulshrestha, Dhawan (bib27) 1999; 65 Silverstein (bib12) 1992; 93 Beroza, Schechter (bib39) 1956; 78 Nandini, Vaidya (bib42) 2019; 8 Enoch, Leaper (bib9) 2005; 23 Leite, Palhano, Almeida, Biavatti (bib30) 2002; 73 Werner, Grose (bib5) 2003; 83 Phan, Lee, Chan, Hughes, Cherry (bib44) 2000; 29 Gosain, DiPietro (bib11) 2004; 28 Powers, Higham, Broussard, Phillips (bib15) 2016; 74 Biswas, Mukherjee (bib31) 2003; 2 Sundarraj, Thangam, Sreevani, Kaveri, Gunasekaran, Achiraman (bib63) 2012; 141 Samak, Shenoy, Manjunatha, Vinayak (bib49) 2009; 115 Moura-Letts, Villegas, Marçalo, Vaisberg, Hammond (bib29) 2006; 69 Harjai, Bala, Gupta, Sharma (bib52) 2013; 69 Södergren, Cederberg, Vessby, Basu (bib61) 2001; 40 Gillitzer, Goebeler (bib4) 2001; 69 Rashed, Afifi, Disi (bib25) 2003; 88 Martinchik (bib40) 2011; 80 Tyagi, Agarwal (bib56) 2017; 6 Velnar, Bailey, Smrkolj (bib10) 2009; 37 Hajialyani, Tewari, Sobarzo-Sánchez, Nabavi, Farzaei, Abdollahi (bib16) 2018; 13 Sheela, Uthayakumari (bib53) 2013; 4 Kiecolt-Glaser, Marucha, Mercado, Malarkey, Glaser (bib14) 1995; 346 Alagammal, Tresina, Mohan (bib59) 2012; 4 Namburi, Priyadarshini, Bullaiah (bib35) 2018; 5 Villegas, Fernández, Maldonado, Torres, Zavaleta, Vaisberg (bib21) 1997; 55 Dhalwal, Deshpande, Purohit, Kadam (bib50) 2005; 43 Al-Rubaye, Kadhim, Hameed (bib60) 2017; 9 Liaqat, Ahmed, Saleem, Masih, Chaudhery (bib55) 2018; 30 Guo, DiPietro (bib1) 2010; 89 Warra, Jonathan, Ibrahim, Adedara (bib38) 2016; 1 Samak, Ballal, Devadiga, Shenoy, Ks (bib51) 2014; 4 Mahadkar, Valvi, Jadhav (bib54) 2013; 6 Barrientos, Stojadinovic, Golinko, Brem, Tomic-Canic (bib6) 2008; 16 Surange, Deokule (bib32) 1987; 6 Hema, Kumaravel, Alagusundaram (bib57) 2011; 7 Inngjerdingen, Nergård, Diallo, Mounkoro, Paulsen (bib22) 2004; 92 Demilew, Adinew, Asrade (bib2) 2018; 2018 Unnikrishnan, Suthindhiran, Jayasri (bib58) 2015; 8 Vaghardoost, Majd, Tebyanian, Babavalian, Malaei, Niazi (bib48) 2018; 7 Chen, Yang, Xue, Wei, Zhang, Chen (bib41) 2011; 16 Singer, Clark (bib3) 1999; 341 Pereira, Bartolo (bib17) 2016; 5 Maver, Maver, Stana Kleinschek, Smrke, Kreft (bib24) 2015; 54 Houghton, Hylands, Mensah, Hensel, Deters (bib46) 2005; 100 Li, Chen, Kirsner (bib7) 2007; 25 Kumar, Vijayakumar, Govindarajan, Pushpangadan (bib18) 2007; 114 Gupta, Singh, Verma (bib34) 2017; 5 Sadaf, Saleem, Ahmed, Ahmad (bib26) 2006; 107 Rodriguez, Wu, Guan (bib47) 2005 Ponnusamy, Banu, Vedigounder, Narayanswamy (bib62) 2018; 10 |
References_xml | – volume: 7 start-page: 80 year: 2011 end-page: 83 ident: bib57 article-title: GC/MS determination of bioactive components of Murraya koenigii publication-title: J Am Sci contributor: fullname: Alagusundaram – volume: 30 start-page: 191 year: 2018 end-page: 194 ident: bib55 article-title: Characterization of natural products from the peel of Lagenaria siceraria fruit using chromatographic techniques publication-title: Acta Chromatogr contributor: fullname: Chaudhery – volume: 6 start-page: 136 year: 2013 end-page: 139 ident: bib54 article-title: Gas Chromatography Mass Spectroscopic (GCMS) analysis of some bioactive compounds form five medicinally relevant wild edible plants publication-title: Asian J Pharmaceut Clin Res contributor: fullname: Jadhav – volume: 28 start-page: 321 year: 2004 end-page: 326 ident: bib11 article-title: Aging and wound healing publication-title: World J Surg contributor: fullname: DiPietro – volume: 1 start-page: 1 year: 2016 end-page: 9 ident: bib38 article-title: GC-MS analysis of hexane extracts of two varieties of sesame (SESAMUN indicum L.) seed oil publication-title: Int J Chem Pharm contributor: fullname: Adedara – volume: 54 start-page: 740 year: 2015 end-page: 751 ident: bib24 article-title: A review of herbal medicines in wound healing publication-title: Int J Dermatol contributor: fullname: Kreft – volume: 77 start-page: 509 year: 1997 end-page: 528 ident: bib8 article-title: General principles of wound healing publication-title: Surg Clin contributor: fullname: Barbul – volume: 16 start-page: 585 year: 2008 end-page: 601 ident: bib6 article-title: Growth factors and cytokines in wound healing publication-title: Wound Repair Regen contributor: fullname: Tomic-Canic – volume: 17 start-page: 91 year: 2004 end-page: 96 ident: bib13 article-title: Bacteria and wound healing publication-title: Curr Opin Infect Dis contributor: fullname: Harding – volume: 346 start-page: 1194 year: 1995 end-page: 1196 ident: bib14 article-title: Slowing of wound healing by psychological stress publication-title: Lancet contributor: fullname: Glaser – volume: 4 start-page: 42 year: 2012 end-page: 44 ident: bib59 article-title: GC-MS determination of bioactive components of Polygala javana DC publication-title: Int J Curr Pharmaceut Res contributor: fullname: Mohan – volume: 141 start-page: 803 year: 2012 end-page: 809 ident: bib63 article-title: γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells publication-title: J Ethnopharmacol contributor: fullname: Achiraman – volume: 88 start-page: 131 year: 2003 end-page: 136 ident: bib25 article-title: Simple evaluation of the wound healing activity of a crude extract of Portulaca oleracea L.(growing in Jordan) in Mus musculus JVI-1 publication-title: J Ethnopharmacol contributor: fullname: Disi – volume: 115 start-page: 631 year: 2009 end-page: 634 ident: bib49 article-title: Superoxide and hydroxyl radical scavenging actions of botanical extracts of Wagatea spicata publication-title: Food Chem contributor: fullname: Vinayak – volume: 119 start-page: 141 year: 2008 end-page: 144 ident: bib23 article-title: Antibacterial, antioxidant and fibroblast growth stimulation of aqueous extracts of Ficus asperifolia Miq. and Gossypium arboreum L., wound-healing plants of Ghana publication-title: J Ethnopharmacol contributor: fullname: Houghton – volume: 93 start-page: S22 year: 1992 end-page: S24 ident: bib12 article-title: Smoking and wound healing publication-title: Am J Med contributor: fullname: Silverstein – volume: 83 start-page: 835 year: 2003 end-page: 870 ident: bib5 article-title: Regulation of wound healing by growth factors and cytokines publication-title: Physiol Rev contributor: fullname: Grose – volume: 100 start-page: 100 year: 2005 end-page: 107 ident: bib46 article-title: In vitro tests and ethnopharmacological investigations: wound healing as an example publication-title: J Ethnopharmacol contributor: fullname: Deters – volume: 16 start-page: 5 year: 2020 end-page: 13 ident: bib43 article-title: Development and validation of a simple HPLC PDA method for the simultaneous analysis of 13-docosenamide, squalene and n-tetracosanol-1 from the leaf extracts of wagatea spicata publication-title: J Stress Physiol Biochem contributor: fullname: Vikas – volume: 114 start-page: 103 year: 2007 end-page: 113 ident: bib18 article-title: Ethnopharmacological approaches to wound healing—exploring medicinal plants of India publication-title: J Ethnopharmacol contributor: fullname: Pushpangadan – volume: 89 start-page: 219 year: 2010 end-page: 229 ident: bib1 article-title: Factors affecting wound healing publication-title: J Dent Res contributor: fullname: DiPietro – volume: 7 start-page: 67 year: 2018 end-page: 71 ident: bib48 article-title: The healing effect of sesame oil, camphor and honey on second degree burn wounds in rat publication-title: World J Plast Surg contributor: fullname: Niazi – volume: 4 start-page: 45 year: 2015 end-page: 52 ident: bib36 article-title: To study the efficacy of kampillakadi tail as-vranaropak in sadyovrana publication-title: Int J Pharmaceut Sci Invent contributor: fullname: Shivram – volume: 23 start-page: 37 year: 2005 end-page: 42 ident: bib9 article-title: Basic science of wound healing publication-title: Surgery contributor: fullname: Leaper – volume: 1 start-page: 1 year: 2009 end-page: 32 ident: bib19 article-title: Wound healing plants of Jalgaon district of Maharashtra state, India publication-title: Ethnobot Leaflets contributor: fullname: Mahajan – volume: 5 start-page: 353 year: 2018 end-page: 358 ident: bib35 article-title: Ayurvedic approach in emergency care: a review publication-title: J Med Sci Clin Res contributor: fullname: Bullaiah – volume: 341 start-page: 738 year: 1999 end-page: 746 ident: bib3 article-title: Cutaneous wound healing publication-title: N Engl J Med contributor: fullname: Clark – volume: 4 start-page: 47 year: 2013 end-page: 53 ident: bib53 article-title: GC-MS analysis of bioactive constituents from coastal sand dune taxon-Sesuvium portulacastrum (L.) publication-title: Biosci Discov contributor: fullname: Uthayakumari – volume: 10 start-page: 194 year: 2018 end-page: 197 ident: bib62 article-title: GC MS/MS analysis of bioactive compounds in alcoholic seed extract of Gauzuma ulmifolia Lam publication-title: Phcog J contributor: fullname: Narayanswamy – volume: 8 start-page: 805 year: 2019 end-page: 810 ident: bib42 article-title: Isolation of active constituents from Wagatea spicata using preparative HPTLC and structural elucidation using FTIR and NMR and GCMS techniques publication-title: J Pharmacogn Phytochem contributor: fullname: Vaidya – volume: 74 start-page: 607 year: 2016 end-page: 625 ident: bib15 article-title: Wound healing and treating wounds: chronic wound care and management publication-title: J Am Acad Dermatol contributor: fullname: Phillips – volume: 69 start-page: 62 year: 2013 end-page: 65 ident: bib52 article-title: Leaf extract of Azadirachta indica (neem): a potential antibiofilm agent for Pseudomonas aeruginosa publication-title: Pathog Dis contributor: fullname: Sharma – volume: 107 start-page: 161 year: 2006 end-page: 163 ident: bib26 article-title: Healing potential of cream containing extract of Sphaeranthus indicus on dermal wounds in Guinea pigs publication-title: J Ethnopharmacol contributor: fullname: Ahmad – volume: 78 start-page: 1242 year: 1956 end-page: 1247 ident: bib39 article-title: The Synthesis of dl-Sesamin and dl-Asarinin1 publication-title: J Am Chem Soc contributor: fullname: Schechter – volume: 69 start-page: 978 year: 2006 end-page: 979 ident: bib29 article-title: In Vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera d iffusa publication-title: J Nat Prod contributor: fullname: Hammond – volume: 6 start-page: 238 year: 1987 end-page: 243 ident: bib32 article-title: Pharmacognistic studies on wagatea spicata dalzell publication-title: Ancient Sci Life contributor: fullname: Deokule – volume: 9 start-page: 163 year: 2017 end-page: 178 ident: bib60 article-title: Determination of bioactive chemical composition of methanolic leaves extract of Sinapis arvensis using GC-MS technique publication-title: Int J Toxicol Pharmacol Res contributor: fullname: Hameed – volume: 80 start-page: 41 year: 2011 end-page: 43 ident: bib40 article-title: Nutritional value of sesame seeds publication-title: Voprosy pitaniia contributor: fullname: Martinchik – volume: 7 start-page: 1 year: 2016 end-page: 6 ident: bib33 article-title: The queen of species and Ayurveda: a brief review publication-title: Int J Res Ayurveda Pharm contributor: fullname: Mohanlal – volume: 25 start-page: 9 year: 2007 end-page: 18 ident: bib7 article-title: Pathophysiology of acute wound healing publication-title: Clin Dermatol contributor: fullname: Kirsner – volume: 65 start-page: 1 year: 1999 end-page: 11 ident: bib27 article-title: In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica publication-title: J Ethnopharmacol contributor: fullname: Dhawan – volume: 73 start-page: 496 year: 2002 end-page: 500 ident: bib30 article-title: Wound healing activity and systemic effects of Vernonia scorpioides extract in Guinea pig publication-title: Fitoterapia contributor: fullname: Biavatti – volume: 13 start-page: 175 year: 2018 end-page: 186 ident: bib45 article-title: Essential oil-loaded lipid nanoparticles for wound healing publication-title: Int J Nanomed contributor: fullname: Cornaglia – start-page: 23 year: 2005 end-page: 29 ident: bib47 article-title: Wound-healing assay publication-title: Cell migration contributor: fullname: Guan – volume: 6 start-page: 195 year: 2017 end-page: 206 ident: bib56 article-title: Phytochemical screening and GC-MS analysis of bioactive constituents in the ethanolic extract of Pistia stratiotes L. and Eichhornia crassipes (Mart.) solms publication-title: J Pharmacogn Phytochem contributor: fullname: Agarwal – volume: 13 start-page: 41 year: 2014 end-page: 49 ident: bib20 article-title: Pharmacological evaluation and chemical standardization of an ayurvedic formulation for wound healing activity publication-title: Int J Low Extrem Wounds contributor: fullname: Biswas – volume: 13 start-page: 5023 year: 2018 end-page: 5043 ident: bib16 article-title: Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems publication-title: Int J Nanomed contributor: fullname: Abdollahi – volume: 10 start-page: 51 year: 2016 ident: bib37 article-title: A clinical study to evaluate the efficacy of Patolyadi Kwath & kampillakadi tail in the management of vrana publication-title: J Ayurv contributor: fullname: Swapna – volume: 16 start-page: 4884 year: 2011 end-page: 4896 ident: bib41 article-title: Comparison of compositions and antimicrobial activities of essential oils from chemically stimulated agarwood, wild agarwood and healthy Aquilaria sinensis (Lour.) Gilg trees publication-title: Molecules. contributor: fullname: Chen – volume: 69 start-page: 513 year: 2001 end-page: 521 ident: bib4 article-title: Chemokines in cutaneous wound healing publication-title: J Leukoc Biol contributor: fullname: Goebeler – volume: 55 start-page: 193 year: 1997 end-page: 200 ident: bib21 article-title: Evaluation of the wound-healing activity of selected traditional medicinal plants from Peru publication-title: J Ethnopharmacol contributor: fullname: Vaisberg – volume: 92 start-page: 233 year: 2004 end-page: 244 ident: bib22 article-title: An ethnopharmacological survey of plants used for wound healing in Dogonland, Mali, West Africa publication-title: J Ethnopharmacol contributor: fullname: Paulsen – volume: 43 start-page: 754 year: 2005 end-page: 761 ident: bib50 article-title: Evaluation of the antioxidant activity of Sida cordifolia publication-title: Pharmaceut Biol contributor: fullname: Kadam – volume: 2 start-page: 25 year: 2003 end-page: 39 ident: bib31 article-title: Plant medicines of Indian origin for wound healing activity: a review publication-title: Int J Low Extrem Wounds contributor: fullname: Mukherjee – volume: 5 start-page: 27502 year: 2017 end-page: 27510 ident: bib34 article-title: Sal (shorea robusta) in vrana ropana (wound healing)-A Clinical Study publication-title: J Med Sci Clin Res contributor: fullname: Verma – volume: 29 start-page: 27 year: 2000 end-page: 36 ident: bib44 article-title: Investigating plant-based medicines for wound healing with the use of cell culture technologies and in vitro models: a review publication-title: Ann Acad Med Singapore contributor: fullname: Cherry – volume: 40 start-page: 10 year: 2001 end-page: 16 ident: bib61 article-title: Vitamin E reduces lipid peroxidation in experimental hepatotoxicity in rats publication-title: Eur J Nutr contributor: fullname: Basu – volume: 37 start-page: 1528 year: 2009 end-page: 1542 ident: bib10 article-title: The wound healing process: an overview of the cellular and molecular mechanisms publication-title: J Int Med Res contributor: fullname: Smrkolj – volume: 4 start-page: 533 year: 2014 end-page: 535 ident: bib51 article-title: Inhibition of Methicillin resistant Staphylococcus aureus by botanical extracts of wagatea spicata publication-title: Int J Pharm Pharmaceut Sci contributor: fullname: Ks – volume: 8 start-page: 148 year: 2015 end-page: 159 ident: bib58 article-title: Antidiabetic potential of marine algae by inhibiting key metabolic enzymes publication-title: Front Life Sci contributor: fullname: Jayasri – volume: 5 start-page: 208 year: 2016 end-page: 229 ident: bib17 article-title: Traditional therapies for skin wound healing publication-title: Adv Wound Care contributor: fullname: Bartolo – volume: 2018 start-page: 9 year: 2018 ident: bib2 article-title: Evaluation of the wound healing activity of the crude extract of leaves of Acanthus polystachyus Delile (Acanthaceae) publication-title: Evid base Compl Alternative Med contributor: fullname: Asrade – volume: 13 start-page: 352 year: 2006 end-page: 358 ident: bib28 article-title: Effect of polysaccharides from Opuntia ficus-indica (L.) cladodes on the healing of dermal wounds in the rat publication-title: Phytomedicine contributor: fullname: Lauriano |
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Snippet | Traditional medicine in form of decoctions has been known for ages to possess wound healing abilities. One such traditional formulation mentioned in Indian... BACKGROUNDTraditional medicine in form of decoctions has been known for ages to possess wound healing abilities. One such traditional formulation mentioned in... Image 1 |
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SubjectTerms | Antimicrobial DPPH Kampillakadi Taila Original Scratch assay Vakeri Wound healing |
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Title | Wound healing potential of Vakeri fortified KampillakadiTaila |
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