Chiral high-performance liquid chromatographic separations of vinca alkaloid analogues on alpha 1-acid glycoprotein and human serum albumin columns

• Published in: Journal of chromatography Vol. 609; no. 1-2; p. 163
• Main Authors: Fitos, I, Visy, J, Simonyi, M, Hermansson, J
• Format: Journal Article
• Language: English
• Published: Netherlands 18.09.1992
• Subjects: Chromatography, High Pressure Liquid - methods; Humans; Hydrogen-Ion Concentration; Molecular Structure; Orosomucoid; Serum Albumin; Stereoisomerism; Vinca Alkaloids - chemistry; Vinca Alkaloids - isolation & purification

Separations of the stereoisomers of a series of tetracyclic and pentacyclic vinca alkaloid analogues having two or three chiral centres were performed on Chiral-AGP and Chiral-HSA high-performance liquid chromatographic columns. Phosphate buffers with pH 5-7 containing 5-35% acetonitrile or 2-propan...