Structure optimization of a leukotriene D 4 antagonist by combinatorial chemistry in solution

• Published in: Bioorganic & medicinal chemistry Vol. 5; no. 3; pp. 493 - 496
• Main Authors: Maehr, Hubert, Yang, Roxana
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.03.1997

Structure optimization of the leukotriene D 4 antagonist Ro24–5913 was attempted by combinatorial chemistry. Three segments in its N-succinyl-3-(2-thiazolylethenyl)anilide skeleton, designated as A, B, and C coincided with the thiazolyl, aniline, and N-acyl moieties, respectively, and were selected...