Expression and immunogenicity of V 3 loop epitopes of HIV-1, isolates SC and WMJ2, inserted in Salmonella flagellin

• Published in: Journal of biotechnology Vol. 56; no. 3; pp. 191 - 203
• Main Authors: Cattozzo, E.M, Stocker, B.A.D, Radaelli, A, De Giuli Morghen, C, Tognon, M
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 28.08.1997
• Subjects: aroA−Salmonella; Flagellin; gp120; V 3 loop; Flagellin; gp120; aroA − Salmonella; V 3 loop

Synthetic oligonucleotides corresponding to specific V 3 loop portions of two HIV-1 isolates, SC and WMJ2, were expressed in the flagella of a Salmonella live-vaccine strain. Expression of the inserted epitopes in flagellin and their exposure at the surface of flagellar filaments were shown by immun...