Age-related decline in humoral immunity caused by the selective loss of T H cells and decline in cellular immunity caused by the impaired migration of inflammatory cells without a loss of T DTH cells in SAMP1 mice

• Published in: Mechanisms of ageing and development Vol. 99; no. 3; pp. 199 - 217
• Main Authors: Toichi, Eiko, Hanada, Keigo, Hosokawa, Tomohide, Higuchi, Keiichi, Hosokawa, Masanori, Imamura, Sadao, Hosono, Masamichi
• Format: Journal Article
• Language: English
• Published: Elsevier Ireland Ltd 30.12.1997
• Subjects: Aging; Antibody response; Delayed-type hypersensitivity; Senescence-accelerated mouse; T cell; Aging; Senescence-accelerated mouse; Delayed-type hypersensitivity; T cell; Antibody response

We investigated the cellular basis of the age-related decline in antibody (Ab) and delayed-type hypersensitivity (DTH) responses to sheep red blood cells (SRBC) in vivo in short-lived senescence-accelerated mouse (SAM) P1. In SAMP1 mice, age-related decreases in CD4 + T cells in the peripheral blood...