Syntheses of T N building blocks N α-(9-fluorenylmethoxycarbonyl)- O-(3,4,6-tri- O-acetyl-2-azido-2-deoxy-α- d-galactopyranosyl)- l-serine/ l-threonine pentafluorophenyl esters: comparison of protocols and elucidation of side reactions

• Published in: Carbohydrate research Vol. 340; no. 7; pp. 1273 - 1285
• Main Authors: Liu, Mian, Young, Victor G., Lohani, Sachin, Live, David, Barany, George
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 23.05.2005
• Subjects: Dehydroalanine; Glycopeptide synthetic building blocks; Glycosylation; Metal ion–carbohydrate complexes; Side reactions; Z-Dehydrothreonine; Side reactions; Glycosylation; Z-Dehydrothreonine; Dehydroalanine; Metal ion–carbohydrate complexes; Glycopeptide synthetic building blocks

[Display omitted] T N antigen building blocks N α-(9-fluorenylmethoxycarbonyl)- O-(3,4,6-tri- O-acetyl-2-azido-2-deoxy-α- d-galactopyranosyl)- l-serine/ l-threonine pentafluorophenyl ester [Fmoc- l-Ser/ l-Thr(Ac 3-α- d-GalN 3)-OPfp, 13/ 14] have been synthesized by two different routes, which have b...