Stimulation by calmodulin of Ca 2+ uptake and (Ca 2+-Mg 2+) ATPase activity in membrane fractions from ox neurohypophyses

Calmodulin stimulated 45Ca 2+ uptake into a plasma membrane enriched fraction from ox neurohypophysial nerve endings and into a microsome fraction. The 45Ca 2+ uptake and the (Ca 2+-Mg 2+) ATPase activity in the plasma membrane fraction exhibited similar pCa and calmodulin sensitivities, suggesting...

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Published inCell calcium (Edinburgh) Vol. 2; no. 2; pp. 125 - 136
Main Authors Conigrave, A.D., Treiman, M., Særmark, T., Thorn, N.A.
Format Journal Article
LanguageEnglish
Published Elsevier India Pvt Ltd 1981
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Summary:Calmodulin stimulated 45Ca 2+ uptake into a plasma membrane enriched fraction from ox neurohypophysial nerve endings and into a microsome fraction. The 45Ca 2+ uptake and the (Ca 2+-Mg 2+) ATPase activity in the plasma membrane fraction exhibited similar pCa and calmodulin sensitivities, suggesting that the enzyme activity is the biochemical expression of a high affinity Ca 2+ pump. Calmodulin thus seems to play a role in regulation of the intracellular free Ca 2+ concentration in the neurohypophysis.
ISSN:0143-4160
1532-1991
DOI:10.1016/0143-4160(81)90029-4