Cariprazine (RGH-188), a potent D 3/D 2 dopamine receptor partial agonist, binds to dopamine D 3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents

• Published in: Neurochemistry international Vol. 59; no. 6; pp. 925 - 935
• Main Authors: Gyertyán, István, Kiss, Béla, Sághy, Katalin, Laszy, Judit, Szabó, Györgyi, Szabados, Tamás, Gémesi, Larisza I., Pásztor, Gabriella, Zájer-Balázs, Mária, Kapás, Margit, Csongor, Éva Ágai, Domány, György, Tihanyi, Károly, Szombathelyi, Zsolt
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.11.2011
• Subjects: Atypical antipsychotic; Cariprazine; Cognitive improvement; D 3/D 2 partial agonist; Dopamine D 3 receptor; Schizophrenia; LLOQ; UV; Atypical antipsychotic; Cariprazine; Dopamine D 3 receptor; MS; SMA; Schizophrenia; D 3/D 2 partial agonist; CAR; LC; NMDA; PCP; HPLC; DOI; Cognitive improvement

[Display omitted] ► Cariprazine, a D 3/D 2 partial agonist potently bound rat D 3 and D 2 receptors in vivo. ► Cariprazine had high potency and efficacy in preclinical antipsychotic screening tests. ► Cariprazine lacked cataleptogenic activity in rats. ► Cariprazine showed procognitive effects in sc...