The effects of 1,25-dihydroxyvitamin D 3 on colon cancer cells depend on RhoA-ROCK-p38MAPK-MSK signaling

• Published in: The Journal of steroid biochemistry and molecular biology Vol. 121; no. 1; pp. 355 - 361
• Main Authors: Ordóñez-Morán, Paloma, Álvarez-Díaz, Silvia, Valle, Noelia, Larriba, María Jesús, Bonilla, Félix, Muñoz, Alberto
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.07.2010
• Subjects: Colon cancer; Cystatin D; Gene regulation; MSK; RhoA; Vitamin D; ROCK; 1,25(OH) 2D 3; Colon cancer; MSK; Vitamin D; VDR; Gene regulation; Cystatin D; MAPK; RhoA

Many studies support a protective action of vitamin D against colon cancer. 1α,25-Dihydroxyvitamin D 3 (1,25(OH) 2D 3) exerts wide gene regulatory effects in human colon cancer cells. We previously reported that 1,25(OH) 2D 3 increases cytosolic Ca 2+ concentration and transiently activates RhoA and...