A minimalist approach to the stereoselective synthesis of 1R-alkoxygenipins

• Published in: Tetrahedron Vol. 161
• Main Authors: He, Yi-Fan, Meng, Fan-cui, Cai, Tian-Tian, Yin-Liu, Xie, Yun-Dong, Zhou, Jing, Yan, Hao, Liu, Ji-Ping, Han, Chao-Jun, Shi, Yong-Heng
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 17.07.2024; Elsevier
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology

The 1R-alkoxygenipins exhibit significantly enhanced bioactivity in comparison to their S-isomers; however, the challenge lies in the selective synthesis of these compounds. A streamlined and highly effective approach to achieve stereoselective 1R-alkyloxygenipins involved the use of a carefully bal...