Dehydroepiandrosterone reduces expression and activity of BACE in NT 2 neurons exposed to oxidative stress

• Published in: Neurobiology of disease Vol. 14; no. 2; pp. 291 - 301
• Main Authors: Tamagno, E, Guglielmotto, M, Bardini, P, Santoro, G, Davit, A, Di Simone, D, Danni, O, Tabaton, M
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 2003
• Subjects: Alzheimer's disease; Antioxidants; BACE; DHEA; NT 2 neurons; Oxidative stress; DHEA; Antioxidants; Oxidative stress; NT 2 neurons; Alzheimer's disease; BACE
• ISSN: 0969-9961; 1095-953X
• DOI: 10.1016/S0969-9961(03)00131-1

Recently, we showed that oxidative stress activates the expression and activity of the β-site AβPP-cleaving enzyme (BACE), an aspartyl protease responsible for the β-secretase cleavage of AβPP. The identification of compounds able to prevent the induction of this event is an important goal of therapeutic strategies for Alzheimer's disease (AD). Dehydroepiandrosterone (DHEA) is an adrenal steroid that improves a variety of functions in the central nervous system. Moreover, a series of evidence suggests that DHEA displays antioxidant properties in different experimental models. In the present paper we show that pretreatment with DHEA is able to rescue the increase of mRNA expression, protein levels, and activity of BACE, produced by oxidative stress in NT 2 neurons. BACE, being the enzyme that initiates the production of Aβ, is a drug target for AD. Our results imply that DHEA administration may slow down the AD pathological process, lowering Aβ accumulation.