Effect on meningococcal serogroup W immunogenicity when Tdap was administered prior, concurrent or subsequent to the quadrivalent (ACWY) meningococcal CRM 197-conjugate vaccine in adult Hajj pilgrims: A randomised controlled trial

• Published in: Vaccine Vol. 37; no. 27; pp. 3562 - 3567
• Main Authors: Tashani, Mohamed, Badahdah, Al-Mamoon, Alfelali, Mohammad, Barasheed, Osamah, Alqahtani, Amani S, Heron, Leon, Wong, Melanie, Louth, Jennifer, Rashid, Harunor, Borrow, Ray, Booy, Robert
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Limited 12.06.2019
• Subjects: Allergy and Immunology; Antibodies; Antigens; Capsular polysaccharides; Compliance; Conjugates; Diphtheria; Immune response; Immune system; Immunity; Immunization; Immunogenicity; Immunology; Industrialized nations; Pertussis; Polysaccharides; Proteins; Public health; Statistical methods; Tetanus; Travellers; Vaccines; Whooping cough; Diphtheria, tetanus, acellular pertussis vaccine; Serum bactericidal antibody; Carrier protein; Vaccine interaction; Meningococcal conjugate vaccine

AbstractImmune responses to the capsular polysaccharide administered in the polysaccharide-protein conjugate vaccines can be either improved or suppressed by the pre-existence of immunity to the carrier protein. Receiving multiple vaccinations is essential for travellers such as Hajj pilgrims, and t...