Regulation of the specific release of arachidonic acid by cytosolic phospholipase A 2

Cytosolic phospholipase A 2 alpha (cPLA 2 α) is the only PLA 2 that exhibits specificity for sn-2 arachidonic acid consistent with its primary role in mediating the agonist-induced release of arachidonic acid for eicosanoid production. It is subject to complex mechanisms of regulation that ensure th...

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Published inProstaglandins, leukotrienes and essential fatty acids Vol. 70; no. 4; pp. 373 - 376
Main Author Leslie, Christina C
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 2004
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Abstract Cytosolic phospholipase A 2 alpha (cPLA 2 α) is the only PLA 2 that exhibits specificity for sn-2 arachidonic acid consistent with its primary role in mediating the agonist-induced release of arachidonic acid for eicosanoid production. It is subject to complex mechanisms of regulation that ensure that levels of free arachidonic acid are tightly controlled. The calcium-induced translocation of cPLA 2 α from the cytosol to membrane regulates its interaction with phospholipid substrate. cPLA 2 α is additionally regulated by phosphorylation on sites in the catalytic domain. Because of its central position as the upstream regulatory enzyme for initiating production of several classes of bioactive lipid mediators (leukotrienes, prostaglandins and platelet-activating factor), it is a potentially important pharmacological target for the control of inflammatory diseases.
AbstractList Cytosolic phospholipase A 2 alpha (cPLA 2 α) is the only PLA 2 that exhibits specificity for sn-2 arachidonic acid consistent with its primary role in mediating the agonist-induced release of arachidonic acid for eicosanoid production. It is subject to complex mechanisms of regulation that ensure that levels of free arachidonic acid are tightly controlled. The calcium-induced translocation of cPLA 2 α from the cytosol to membrane regulates its interaction with phospholipid substrate. cPLA 2 α is additionally regulated by phosphorylation on sites in the catalytic domain. Because of its central position as the upstream regulatory enzyme for initiating production of several classes of bioactive lipid mediators (leukotrienes, prostaglandins and platelet-activating factor), it is a potentially important pharmacological target for the control of inflammatory diseases.
Author Leslie, Christina C
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References Nakamura, Nara (BIB18) 2003; 68
Nalefski, Sultzman, Martin (BIB36) 1994; 269
Leslie (BIB10) 1991; 266
Sundler, Winstedt, Wijkander (BIB28) 1994; 301
Song, Chang, Bean, Proia, Knopf, Kriz (BIB11) 1999; 274
Jump (BIB24) 2002; 277
Kudo, Murakami (BIB1) 2002; 68–69
Balsinde, Balboa, Dennis (BIB8) 1997; 272
Evans, Spencer, Zweifach, Leslie (BIB38) 2001; 276
Leslie, Voelker, Channon, Wall, Zelarney (BIB27) 1988; 963
Jenkins, Han, Yang (BIB14) 2003; 42
Diez, Louis-Flamberg, Hall, Mayer (BIB25) 1992; 267
Yamashita, Sugiura, Waku (BIB19) 1997; 122
Channon, Leslie (BIB35) 1990; 265
Das, Rafter, Kim, Gygi, Cho (BIB53) 2003; 278
Strokin, Sergeeva, Reiser (BIB33) 2003; 139
C.R. Yellaturu, G.N. Rao, A requirement for calcium-independent phospholipase A
Evans, Gerber, Murray, Leslie (BIB44) 2004; 15
Ghomashchi, Stewart, Hefner (BIB34) 2001; 1513
Hanel, Schüttel, Gelb (BIB26) 1993; 32
Ramanadham, Hsu, Bohrer, Ma, Turk (BIB7) 1999; 274
de Carvalho, McCormack, Olson (BIB49) 1996; 271
Winstead, Balsinde, Dennis (BIB4) 2000; 1488
Lin, Wartmann, Lin, Knopf, Seth, Davis (BIB48) 1993; 72
Murakami, Kudo (BIB3) 2001; 77
C.C. Leslie, Regulation of arachidonic acid availability for eicosanoid production. Biochem. Cell Biol., 2004, in press.
Evans, Fergus, Leslie (BIB54) 2002; 3
Zhou, Nilsson (BIB20) 2001; 42
Muthalif, Hefner, Canaan (BIB51) 2001; 276
Qiu, Gijón, de Carvalho, Spencer, Leslie (BIB52) 1998; 273
Funk (BIB23) 2001; 294
Feng, Wehbi, Roberts (BIB46) 2002; 277
Clark, Lin, Kriz (BIB29) 1991; 65
Shikano, Masuzawa, Yazawa, Takayama, Kuko, Inoue (BIB31) 1994; 1212
Stewart, Ghosh, Spencer, Leslie (BIB9) 2002; 277
Jenkins, Han, Mancuso, Gross (BIB6) 2002; 277
Pickard, Strifler, Kramer, Sharp (BIB12) 1999; 274
Contreras, Rapoport (BIB32) 2002; 13
Underwood, Song, Kriz, Chang, Knopf, Lin (BIB13) 1998; 273
Evans, Leslie (BIB45) 2004; 279
Salem, Litman, Kim, Gawrisch (BIB22) 2001; 36
Valentin, Lambeau (BIB2) 2000; 1488
Bittova, Sumandea, Cho (BIB43) 1999; 274
Gijón, Spencer, Kaiser, Leslie (BIB37) 1999; 145
Han, Kim, Koduri (BIB47) 1999; 274
Perisic, Paterson, Mosedale, Lara-González, Williams (BIB39) 1999; 274
in thrombin-induced arachidonic acid release and growth in vascular smooth muscle cells, J. Biol. Chem. 278 (2003) 43831–43837.
Perisic, Fong, Lynch, Bycroft, Williams (BIB41) 1998; 273
Spector (BIB21) 1999; 34
Hefner, Borsch-Haubold, Murakami (BIB50) 2000; 275
Leslie (BIB17) 1997; 272
de Carvalho, Garritano, Leslie (BIB30) 1995; 270
Rizo, Südhof (BIB40) 1998; 273
Ball, Nielsen, Gelb, Robinson (BIB42) 1999; 96
Clark, Schievella, Nalefski, Lin (BIB16) 1995; 12
References_xml – reference: C.R. Yellaturu, G.N. Rao, A requirement for calcium-independent phospholipase A
– volume: 274
  start-page: 17063
  year: 1999
  end-page: 17067
  ident: BIB11
  article-title: Molecular characterization of cytosolic phospholipase A
  publication-title: J. Biol. Chem.
– volume: 68
  start-page: 145
  year: 2003
  end-page: 150
  ident: BIB18
  article-title: Essential fatty acid synthesis and its regulation in mammals
  publication-title: Prostaglandins Leukot. Essent. Fatty Acids
– volume: 279
  start-page: 6005
  year: 2004
  end-page: 6016
  ident: BIB45
  article-title: The cytosolic phospholipase A catalytic domain modulates association and residence time at Golgi membranes
  publication-title: J. Biol. Chem.
– volume: 68–69
  start-page: 3
  year: 2002
  end-page: 58
  ident: BIB1
  article-title: Phospholipase A
  publication-title: Prostagland. Other Lipid Mediat.
– volume: 265
  start-page: 5409
  year: 1990
  end-page: 5413
  ident: BIB35
  article-title: A calcium-dependent mechanism for associating a soluble arachidonoyl-hydrolyzing phospholipase A
  publication-title: J. Biol. Chem.
– volume: 96
  start-page: 6637
  year: 1999
  end-page: 6642
  ident: BIB42
  article-title: Interfacial membrane docking of cytosolic phospholipase A
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 266
  start-page: 11366
  year: 1991
  end-page: 11371
  ident: BIB10
  article-title: Kinetic properties of a high molecular mass arachidonoyl-hydrolyzing phospholipase A
  publication-title: J. Biol. Chem.
– volume: 12
  start-page: 83
  year: 1995
  end-page: 117
  ident: BIB16
  article-title: Cytosolic phospholipase A
  publication-title: J Lipid Mediat. Cell Signal
– volume: 269
  start-page: 18239
  year: 1994
  end-page: 18249
  ident: BIB36
  article-title: Delineation of two functionally distinct domains of cytosolic phospholipase A
  publication-title: J. Biol. Chem.
– volume: 273
  start-page: 1596
  year: 1998
  end-page: 1604
  ident: BIB41
  article-title: Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A
  publication-title: J. Biol. Chem.
– volume: 36
  start-page: 945
  year: 2001
  end-page: 959
  ident: BIB22
  article-title: Mechanisms of action of docosahexaenoic acid in the nervous system
  publication-title: Lipids
– volume: 139
  start-page: 1014
  year: 2003
  end-page: 1022
  ident: BIB33
  article-title: Docosahexaenoic acid, arachidonic acid release in rat brain astocytes is mediated by two separate isoforms of phospholipase A
  publication-title: Br. J. Pharmacol.
– volume: 277
  start-page: 29526
  year: 2002
  end-page: 29536
  ident: BIB9
  article-title: Enzymatic properties of human cytosolic phospholipase A
  publication-title: J. Biol. Chem.
– volume: 3
  start-page: 30
  year: 2002
  ident: BIB54
  article-title: Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA
  publication-title: BMC Biochem. Comput. File
– volume: 294
  start-page: 1871
  year: 2001
  end-page: 1875
  ident: BIB23
  article-title: Prostaglandins and leukotrienes
  publication-title: Science
– volume: 277
  start-page: 8755
  year: 2002
  end-page: 8758
  ident: BIB24
  article-title: The biochemistry of
  publication-title: J. Biol. Chem.
– volume: 273
  start-page: 21926
  year: 1998
  end-page: 21932
  ident: BIB13
  article-title: A novel calcium-independent phospholipase A
  publication-title: J. Biol. Chem.
– volume: 277
  start-page: 32807
  year: 2002
  end-page: 32814
  ident: BIB6
  article-title: Identification of calcium-independent phospholipase A
  publication-title: J. Biol. Chem.
– volume: 34
  start-page: S1
  year: 1999
  end-page: S3
  ident: BIB21
  article-title: Essentiality of fatty acids
  publication-title: Lipids
– volume: 77
  start-page: 163
  year: 2001
  end-page: 194
  ident: BIB3
  article-title: Diversity and regulatory functions of mammalian secretory phospholipase A
  publication-title: Adv. Immunol.
– volume: 1212
  start-page: 211
  year: 1994
  end-page: 216
  ident: BIB31
  article-title: Complete discrimination of docosahexaenoate from arachidonate by 85
  publication-title: Biochim. Biophys. Acta
– volume: 963
  start-page: 476
  year: 1988
  end-page: 492
  ident: BIB27
  article-title: Properties and purification of an arachidonoyl-hydrolyzing phospholipase A
  publication-title: Biochim. Biophys. Acta
– volume: 1488
  start-page: 59
  year: 2000
  end-page: 70
  ident: BIB2
  article-title: Increasing molecular diversity of secreted phospholipases A
  publication-title: Biochim. Biophys. Acta
– volume: 272
  start-page: 29317
  year: 1997
  end-page: 29321
  ident: BIB8
  article-title: Antisense inhibition of group VI Ca
  publication-title: J. Biol. Chem.
– volume: 15
  start-page: 371
  year: 2004
  end-page: 383
  ident: BIB44
  article-title: The calcium binding loops of the cytosolic phospholipase A
  publication-title: Mol. Biol. Cell
– volume: 274
  start-page: 14979
  year: 1999
  end-page: 14987
  ident: BIB39
  article-title: Mapping the phospholipid-binding surface and translocation determinants of the C2 domain from cytosolic phospholipase A
  publication-title: J. Biol. Chem.
– volume: 274
  start-page: 13915
  year: 1999
  end-page: 13927
  ident: BIB7
  article-title: Studies of the role of group VI phospholipase A
  publication-title: J. Biol. Chem.
– volume: 13
  start-page: 267
  year: 2002
  end-page: 272
  ident: BIB32
  article-title: Recent studies on interactions between
  publication-title: Curr. Opin. Lipidol.
– volume: 276
  start-page: 39653
  year: 2001
  end-page: 39660
  ident: BIB51
  article-title: Functional interaction of calcium-/calmodulin-dependent protein kinase II and cytosolic phospholipase A
  publication-title: J. Biol. Chem.
– volume: 274
  start-page: 11881
  year: 1999
  end-page: 11888
  ident: BIB47
  article-title: Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A
  publication-title: J. Biol. Chem.
– volume: 277
  start-page: 19867
  year: 2002
  end-page: 19875
  ident: BIB46
  article-title: Role of tryptophan residues in interfacial binding of phosphatidylinositol-specific phospholipase C
  publication-title: J. Biol. Chem.
– volume: 271
  start-page: 6987
  year: 1996
  end-page: 6997
  ident: BIB49
  article-title: Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A
  publication-title: J. Biol. Chem.
– volume: 278
  start-page: 41431
  year: 2003
  end-page: 41442
  ident: BIB53
  article-title: Mechanism of group IVA cytosolic phospholipase A
  publication-title: J. Biol. Chem.
– reference: in thrombin-induced arachidonic acid release and growth in vascular smooth muscle cells, J. Biol. Chem. 278 (2003) 43831–43837.
– volume: 272
  start-page: 16709
  year: 1997
  end-page: 16712
  ident: BIB17
  article-title: Properties and regulation of cytosolic phospholipase A
  publication-title: J. Biol. Chem.
– volume: 1488
  start-page: 28
  year: 2000
  end-page: 39
  ident: BIB4
  article-title: Calcium-independent phospholipase A
  publication-title: Biochim. Biophys. Acta
– volume: 273
  start-page: 8203
  year: 1998
  end-page: 8211
  ident: BIB52
  article-title: The role of calcium and phosphorylation of cytosolic phospholipase A
  publication-title: J. Biol. Chem.
– volume: 42
  start-page: 11798
  year: 2003
  end-page: 11807
  ident: BIB14
  article-title: Purification of recombinant human cPLA
  publication-title: Biochemistry
– volume: 274
  start-page: 8823
  year: 1999
  end-page: 8831
  ident: BIB12
  article-title: Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A
  publication-title: J. Biol. Chem.
– volume: 273
  start-page: 15879
  year: 1998
  end-page: 15882
  ident: BIB40
  article-title: C2-domains, structure and function of a universal Ca
  publication-title: J. Biol. Chem.
– volume: 72
  start-page: 269
  year: 1993
  end-page: 278
  ident: BIB48
  article-title: cPLA
  publication-title: Cell
– volume: 32
  start-page: 5949
  year: 1993
  end-page: 5958
  ident: BIB26
  article-title: Processive interfacial catalysis by mammalian 85-kilodalton phospholipase A
  publication-title: Biochemistry
– volume: 270
  start-page: 20439
  year: 1995
  end-page: 20446
  ident: BIB30
  article-title: Regulation of lysophospholipase activity of the 85-kDa phospholipase A
  publication-title: J. Biol. Chem.
– volume: 275
  start-page: 37542
  year: 2000
  end-page: 37551
  ident: BIB50
  article-title: Serine 727 phosphorylation and activation of cytosolic phospholipase A
  publication-title: J. Biol. Chem.
– volume: 42
  start-page: 1521
  year: 2001
  end-page: 1542
  ident: BIB20
  article-title: Sources of eicosanoid precursor fatty acid pools in tissues
  publication-title: J. Lipid Res.
– volume: 301
  start-page: 455
  year: 1994
  end-page: 458
  ident: BIB28
  article-title: Acyl-chain selectivity of the 85
  publication-title: Biochem. J.
– volume: 274
  start-page: 9665
  year: 1999
  end-page: 9672
  ident: BIB43
  article-title: A structure-function study of the C2 domain of cytosolic phospholipase A
  publication-title: J. Biol. Chem.
– volume: 276
  start-page: 30150
  year: 2001
  end-page: 30160
  ident: BIB38
  article-title: Intracellular calcium signals regulating cytosolic phospholipase A
  publication-title: J. Biol. Chem.
– volume: 65
  start-page: 1043
  year: 1991
  end-page: 1051
  ident: BIB29
  article-title: A novel arachidonic acid-selective cytosolic PLA
  publication-title: Cell
– volume: 145
  start-page: 1219
  year: 1999
  end-page: 1232
  ident: BIB37
  article-title: Role of phosphorylation sites and the C2 domain in regulation of cytosolic phospholipase A
  publication-title: J. Cell Biol.
– reference: C.C. Leslie, Regulation of arachidonic acid availability for eicosanoid production. Biochem. Cell Biol., 2004, in press.
– volume: 122
  start-page: 1
  year: 1997
  end-page: 16
  ident: BIB19
  article-title: Acyltransferases and transacylases involved in fatty acid remodeling of phospholipids and metabolism of bioactive lipids in mammalian cells
  publication-title: J. Biochem. (Tokyo)
– volume: 267
  start-page: 18342
  year: 1992
  end-page: 18348
  ident: BIB25
  article-title: Substrate specificities and properties of human phospholipase A
  publication-title: J. Biol. Chem.
– volume: 1513
  start-page: 160
  year: 2001
  end-page: 166
  ident: BIB34
  article-title: A pyrrolidine-based specific inhibitor of cytosolic phospholipase A
  publication-title: Biochim. Biophys. Acta
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Snippet Cytosolic phospholipase A 2 alpha (cPLA 2 α) is the only PLA 2 that exhibits specificity for sn-2 arachidonic acid consistent with its primary role in...
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Title Regulation of the specific release of arachidonic acid by cytosolic phospholipase A 2
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