腹膜糖转运及钠-葡萄糖共转运蛋白2抑制剂在腹膜透析领域的研究进展

钠-葡萄糖共转运蛋白(sodium-glucose co-transporter,SGLT)2抑制剂是目前临床广泛使用的新药物,已知SGLT2抑制剂可以通过阻断SGLT2减少近端肾小管细胞对葡萄糖的重吸收来降低 2型糖尿病患者的血糖.同时,该药物可为糖尿病及非糖尿病患者带来显著的肾脏及心血管获益.腹膜透析患者的人腹膜间皮细胞可表达SGLT.关于SGLT2抑制剂在腹膜透析领域的研究已有体外或动物实验报道,提示接受PD治疗的患者应用SGLT2抑制剂,可减少腹膜葡萄糖吸收,可能延迟腹膜纤维化的进展.同时,腹膜寿命的延长及转运功能的维持有利于保证透析充分性,改善患者预后.但是SGLT2抑制剂在腹膜透析...

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Published inLinchuang Shenzangbing Zazhi Vol. 23; no. 11; pp. 946 - 950
Main Authors 杨帆, 刘聪慧, 王小琪, 刘小菁, 史亚男, 李忠心
Format Journal Article
LanguageChinese
Published 首都医科大学附属北京潞河医院肾病中心,北京 101149 2023
Editorial Department of Journal of Clinical Nephrology
Subjects
Sodium-glucose transport proteins
腹膜透析
Peritoneal mesothelial cells
糖转运
Glucose transport
腹膜间皮细胞
Peritoneal dialysis
钠-葡萄糖转运蛋白质类
Online AccessGet full text
ISSN1671-2390
DOI10.3969/j.issn.1671-2390.2023.11.010

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Abstract 钠-葡萄糖共转运蛋白(sodium-glucose co-transporter,SGLT)2抑制剂是目前临床广泛使用的新药物,已知SGLT2抑制剂可以通过阻断SGLT2减少近端肾小管细胞对葡萄糖的重吸收来降低 2型糖尿病患者的血糖.同时,该药物可为糖尿病及非糖尿病患者带来显著的肾脏及心血管获益.腹膜透析患者的人腹膜间皮细胞可表达SGLT.关于SGLT2抑制剂在腹膜透析领域的研究已有体外或动物实验报道,提示接受PD治疗的患者应用SGLT2抑制剂,可减少腹膜葡萄糖吸收,可能延迟腹膜纤维化的进展.同时,腹膜寿命的延长及转运功能的维持有利于保证透析充分性,改善患者预后.但是SGLT2抑制剂在腹膜透析领域的应用尚未引起广泛关注.本文将就腹膜糖代谢及SGLT2抑制剂在腹膜透析领域的研究进展做一综述.
AbstractList 钠-葡萄糖共转运蛋白(sodium-glucose co-transporter,SGLT)2抑制剂是目前临床广泛使用的新药物,已知SGLT2抑制剂可以通过阻断SGLT2减少近端肾小管细胞对葡萄糖的重吸收来降低 2型糖尿病患者的血糖.同时,该药物可为糖尿病及非糖尿病患者带来显著的肾脏及心血管获益.腹膜透析患者的人腹膜间皮细胞可表达SGLT.关于SGLT2抑制剂在腹膜透析领域的研究已有体外或动物实验报道,提示接受PD治疗的患者应用SGLT2抑制剂,可减少腹膜葡萄糖吸收,可能延迟腹膜纤维化的进展.同时,腹膜寿命的延长及转运功能的维持有利于保证透析充分性,改善患者预后.但是SGLT2抑制剂在腹膜透析领域的应用尚未引起广泛关注.本文将就腹膜糖代谢及SGLT2抑制剂在腹膜透析领域的研究进展做一综述.
Author 刘聪慧
杨帆
史亚男
王小琪
刘小菁
李忠心
AuthorAffiliation 首都医科大学附属北京潞河医院肾病中心,北京 101149
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Author_FL Yang Fan
Shi Ya-nan
Li Zhong-xin
Liu Xiao-jing
Liu Cong-hui
Wang Xiao-qi
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  fullname: Li Zhong-xin
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DocumentTitle_FL Current developments in peritoneal glucose transport and sodium-glucose co-transporter 2 in-hibitors during peritoneal dialysis
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Issue 11
Keywords Sodium-glucose transport proteins
腹膜透析
Peritoneal mesothelial cells
糖转运
Glucose transport
腹膜间皮细胞
Peritoneal dialysis
钠-葡萄糖转运蛋白质类
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PublicationTitle_FL Journal of Clinical Nephrology
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Editorial Department of Journal of Clinical Nephrology
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Snippet 钠-葡萄糖共转运蛋白(sodium-glucose co-transporter,SGLT)2抑制剂是目前临床广泛使用的新药物,已知SGLT2抑制剂可以通过阻断SGLT2减少近端肾小管细胞对葡萄糖的重吸收来降低...
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Title 腹膜糖转运及钠-葡萄糖共转运蛋白2抑制剂在腹膜透析领域的研究进展
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