初级侧支循环对脑血流自动调节功能的影响

ACoA和PCoA对dCA功能的影响尚不清楚.本研究旨在探究初级侧支循环的解剖差异对dCA功能的影响.根据DSA影像特点将分为两组:孤立的BA和(或)双侧VA严重狭窄/闭塞组(组1A:双侧PCoAs存在;组1B:双侧PCoAs缺如);孤立的单侧ICA严重狭窄/闭塞(组2A:无ACoA而存在同侧PCoA;组2B:存在ACoA而无PCoAs;组2C:无ACoA和PCoA).使用传递函数法评估MCA和(或)PCA的dCA功能.在2014-2017年间接受dCA评估和DSA检查的231例非急性期缺血性卒中患者中,有51例患者符合纳入标准,其中21例患者被纳入组1,30例患者被纳入组2.组1A与1B、2...

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Published inZhongguo cuzhong zazhi Vol. 14; no. 3; pp. 240 - 247
Main Authors 郭珍妮, 孙欣, 刘嘉, 孙惠杰, 赵英凯, 马虹印, 徐保峰, 王钟秀, 李超, 颜秀丽, 周宏伟, 张鹏, 靳航, 杨弋, 王焱
Format Journal Article
LanguageChinese
Published 吉林大学第一医院脑血管病临床试验与临床研究中心%130021,长春吉林大学第一医院神经内科%中科院深圳先进技术研究院%吉林大学第一医院干部病房%吉林大学第一医院神经外科%吉林大学第一医院放射科%吉林大学第一医院脑血管病临床试验与临床研究中心 01.03.2019
130021 长春吉林大学第一医院神经内科
Editorial Department of Chinese Journal of Stroke
Subjects
前交通动脉
动态脑血流自动调节
后交通动脉
数字减影血管造影
脑血管狭窄
Digital subtraction angiography
Cerebrovasculastenosis
Anteriocommunicating artery
数字减影血管造影
后交通动脉
Dynamic cerebral autoregulation
脑血管狭窄
动态脑血流自动调节
Posteriocommunicating artery
前交通动脉
Online AccessGet full text
ISSN1673-5765
DOI10.3969/j.issn.1673-5765.2019.03.008

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Abstract ACoA和PCoA对dCA功能的影响尚不清楚.本研究旨在探究初级侧支循环的解剖差异对dCA功能的影响.根据DSA影像特点将分为两组:孤立的BA和(或)双侧VA严重狭窄/闭塞组(组1A:双侧PCoAs存在;组1B:双侧PCoAs缺如);孤立的单侧ICA严重狭窄/闭塞(组2A:无ACoA而存在同侧PCoA;组2B:存在ACoA而无PCoAs;组2C:无ACoA和PCoA).使用传递函数法评估MCA和(或)PCA的dCA功能.在2014-2017年间接受dCA评估和DSA检查的231例非急性期缺血性卒中患者中,有51例患者符合纳入标准,其中21例患者被纳入组1,30例患者被纳入组2.组1A与1B、2A与2B及2C组患者之间在性别、年龄和平均动脉压方面均无显著差异.组1中,存在PCoAs的患者PCA相位差(自动调节参数)显著高于PCoAs缺如者.组2中,MCA相位差在有ACoA患者中显著高于无ACoA患者.本研究发现,ACoA/PCoA的开放可以代偿缺血区受损的dCA功能,这表明ACoA/PCoA在维持脑血流的稳定中发挥着重要的作用.
AbstractList ACoA和PCoA对dCA功能的影响尚不清楚.本研究旨在探究初级侧支循环的解剖差异对dCA功能的影响.根据DSA影像特点将分为两组:孤立的BA和(或)双侧VA严重狭窄/闭塞组(组1A:双侧PCoAs存在;组1B:双侧PCoAs缺如);孤立的单侧ICA严重狭窄/闭塞(组2A:无ACoA而存在同侧PCoA;组2B:存在ACoA而无PCoAs;组2C:无ACoA和PCoA).使用传递函数法评估MCA和(或)PCA的dCA功能.在2014-2017年间接受dCA评估和DSA检查的231例非急性期缺血性卒中患者中,有51例患者符合纳入标准,其中21例患者被纳入组1,30例患者被纳入组2.组1A与1B、2A与2B及2C组患者之间在性别、年龄和平均动脉压方面均无显著差异.组1中,存在PCoAs的患者PCA相位差(自动调节参数)显著高于PCoAs缺如者.组2中,MCA相位差在有ACoA患者中显著高于无ACoA患者.本研究发现,ACoA/PCoA的开放可以代偿缺血区受损的dCA功能,这表明ACoA/PCoA在维持脑血流的稳定中发挥着重要的作用.
Abstract_FL The influence of the anterior and posterior communicating artery (ACoA and PCoA) on dCA is largely unknown. In this study, we aimed to test whether substantial differences in collateral anatomy were associated with differences in dCA in two common types of stenosis according to DSA: either isolated basal artery and/or bilateral vertebral arteries severe stenosis/occlusion (group 1A: with bilateral PCoAs; and group 1B: without bilateral PCoAs), or isolated unilateral internal carotid artery severe stenosis/occlusion (group 2A: without ACoA and with PCoA; group 2B: with ACoA and without PCoAs; and group 2C: without both ACoA and PCoA). The dCA was calculated by transfer function analysis (a mathematical model), and was evaluated in MCA and/or PCA. Of a total of 231 non-acute phase ischemic stroke patients who received both dCA assessment and DSA in our lab between 2014 and 2017, 51 patients met inclusion criteria based on the presence or absence of ACoA or PCoA, including 21 patients in the group 1, and 30 patients in the group 2. There were no significant differences in gender, age, and mean blood pressure between group 1A and group 1B, and among group 2A, group 2B, and group 2C. In group 1, the PCA phase difference values (autoregulatory parameter) were significantly higher in the subgroup with patent PCoAs, compared to those without. In group 2, the MCA phase difference values were higher in the subgroup with patent ACoA, compared to those without. This pilot study found that the cross-flow of the ACoA/PCoA to the affected area compensates for compromised dCA in the affected area, which suggests an important role of the ACoA/PCoA in stabilizing cerebral blood flow.
Author 郭珍妮
孙欣
张鹏
靳航
王钟秀
王焱
孙惠杰
杨弋
赵英凯
周宏伟
颜秀丽
徐保峰
马虹印
李超
刘嘉
AuthorAffiliation 130021 长春吉林大学第一医院神经内科;吉林大学第一医院脑血管病临床试验与临床研究中心%130021,长春吉林大学第一医院神经内科%中科院深圳先进技术研究院%吉林大学第一医院干部病房%吉林大学第一医院神经外科%吉林大学第一医院放射科%吉林大学第一医院脑血管病临床试验与临床研究中心
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Author_FL MA Hong-Yin
WANG Yan
SUN Xin
XU Bao-Feng
WANG Zhong-Xiu
GUO Zhen-Ni
SUN Hui-Jie
ZHAO Ying-Kai
YANG Yi
LIU Jia
YAN Xiu-Li
ZHOU Hong-Wei
ZHANG Peng
LI Chao
JIN Hang
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Keywords Digital subtraction angiography
Cerebrovasculastenosis
Anteriocommunicating artery
数字减影血管造影
后交通动脉
Dynamic cerebral autoregulation
脑血管狭窄
动态脑血流自动调节
Posteriocommunicating artery
前交通动脉
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Publisher 吉林大学第一医院脑血管病临床试验与临床研究中心%130021,长春吉林大学第一医院神经内科%中科院深圳先进技术研究院%吉林大学第一医院干部病房%吉林大学第一医院神经外科%吉林大学第一医院放射科%吉林大学第一医院脑血管病临床试验与临床研究中心
130021 长春吉林大学第一医院神经内科
Editorial Department of Chinese Journal of Stroke
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SubjectTerms 前交通动脉
动态脑血流自动调节
后交通动脉
数字减影血管造影
脑血管狭窄
Title 初级侧支循环对脑血流自动调节功能的影响
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