卒中后吞咽障碍的分子生物学研究进展

卒中后吞咽障碍是卒中后常见并发症,指患者由于卒中导致吞咽过程中的困难表现,其发生、发展的分子机制尚未阐明.调控吞咽功能的两个关键区域孤束核和疑核,其分泌的多种神经递质与吞咽功能密切相关.与孤束核密切相关的5-羟色胺(5-hydroxytryptamine,5-HT)及其受体5-HT1A、谷氨酸及N-甲基-D-天冬氨酸受体(N-methyl-D-aspartate receptor,NMDAR)等递质,以及与疑核密切相关的生长激素抑制素、一氧化氮合酶能神经元、谷氨酸、γ-氨基丁酸等递质,在吞咽的启动、控制及相关活动中发挥了重要作用.本文结合当前分子生物学领域最新成果发现,卒中后吞咽障碍可能的发病...

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Published inZhongguo cuzhong zazhi Vol. 17; no. 3; pp. 318 - 323
Main Authors 华晓琼, 李彦杰, 金小琴, 刘昊源, 张淑芹, 牛丽
Format Journal Article
LanguageChinese
Published 郑州 450046 河南中医药大学康复医学院%河南省中医院康复科 01.03.2022
Editorial Department of Chinese Journal of Stroke
Subjects
吞咽障碍，卒中，分子生物学，研究进展
吞咽障碍;卒中;分子生物学;研究进展
Online AccessGet full text
ISSN1673-5765
DOI10.3969/j.issn.1673-5765.2022.03.016

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Abstract 卒中后吞咽障碍是卒中后常见并发症,指患者由于卒中导致吞咽过程中的困难表现,其发生、发展的分子机制尚未阐明.调控吞咽功能的两个关键区域孤束核和疑核,其分泌的多种神经递质与吞咽功能密切相关.与孤束核密切相关的5-羟色胺(5-hydroxytryptamine,5-HT)及其受体5-HT1A、谷氨酸及N-甲基-D-天冬氨酸受体(N-methyl-D-aspartate receptor,NMDAR)等递质,以及与疑核密切相关的生长激素抑制素、一氧化氮合酶能神经元、谷氨酸、γ-氨基丁酸等递质,在吞咽的启动、控制及相关活动中发挥了重要作用.本文结合当前分子生物学领域最新成果发现,卒中后吞咽障碍可能的发病机制与背侧区的孤束核及周围的网状结构组成的脑干吞咽中枢,以及位于腹侧区的疑核及周围的网状结构密切相关.
AbstractList 卒中后吞咽障碍是卒中后常见并发症,指患者由于卒中导致吞咽过程中的困难表现,其发生、发展的分子机制尚未阐明.调控吞咽功能的两个关键区域孤束核和疑核,其分泌的多种神经递质与吞咽功能密切相关.与孤束核密切相关的5-羟色胺(5-hydroxytryptamine,5-HT)及其受体5-HT1A、谷氨酸及N-甲基-D-天冬氨酸受体(N-methyl-D-aspartate receptor,NMDAR)等递质,以及与疑核密切相关的生长激素抑制素、一氧化氮合酶能神经元、谷氨酸、γ-氨基丁酸等递质,在吞咽的启动、控制及相关活动中发挥了重要作用.本文结合当前分子生物学领域最新成果发现,卒中后吞咽障碍可能的发病机制与背侧区的孤束核及周围的网状结构组成的脑干吞咽中枢,以及位于腹侧区的疑核及周围的网状结构密切相关.
Author 金小琴
华晓琼
张淑芹
牛丽
刘昊源
李彦杰
AuthorAffiliation 郑州 450046 河南中医药大学康复医学院%河南省中医院康复科
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HUA Xiaoqiong
LI Yanjie
NIU Li
JIN Xiaoqin
LIU Haoyuan
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Title 卒中后吞咽障碍的分子生物学研究进展
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