Survival analysis of postoperative recurrence of meningioma: 176 cases report

• Published in: Zhongguo xian dai shen jing ji bing za zhi Vol. 22; no. 11; pp. 993 - 999
• Main Authors: Guan⁃you HUANG, Shu⁃yu HAO, WANG, Liang, Li⁃wei ZHANG, Jun⁃ting ZHANG, WU, Zhen
• Format: Journal Article
• Language: Chinese; English
• Published: Tianjin Shi Tianjin Huanhu Hospital 01.11.2022
• Subjects: Edema; meningioma; microsurgery; progression⁃ free survival; proportional hazards models; recurrence; Survival analysis
• ISSN: 1672-6731
• DOI: 10.3969/j.issn.1672⁃6731.2022.11.012

Objective To investigate the influencing factors of postoperative meningioma recurrence. Methods A total of 176 patients with meningioma treated in Beijing Tiantan Hospital, Capital Medical University from May 2010 to January 2011 were included. The general information, imaging findings, extent of tumor resection and postoperative pathological results were analyzed. Kaplan⁃Meier survival curve comparison and Log⁃rank test were used to compare the related influencing factors of meningioma recurrence. Multifactor Cox's proportional hazards regression model was used for survival analysis. Results The median progression free survival (PFS) of patients with preoperative Karnofsky Performance Status (KPS)＜70 was lower than that with KPS≥70 [(8.04±1.98) years vs. (8.08±1.18) years; χ2=5.370, P=0.020]. The median PFS of patients with peritumoral edema grade 2-3 was lower than that with peritumoral edema grade 0-1 [(8.05±1.79) years vs. (8.06±1.09) years; χ2=9.805, P=0.002]. The median PFS of patients with dural mater invasion was lower than that without dural mater invasion [(7.97±1.70) years vs. (8.06±1.09) years; χ2=12.357, P=0.000]. The median PFS of patients with WHO grade 2-3 was lower than that with WHO grade 1 [(5.14±2.07) years vs. (8.12±0.87) years; χ2=113.774, P=0.000]. Multivariate Cox's proportional hazards regression model showed that WHO grade 2-3 could increase the risk of postoperative meningioma recurrence (RR=15.693, 95%CI: 5.905-41.707; P=0.000). Conclusions The preoperative KPS score, peritumoral edema, dura mater invasion and WHO grade may affect the recurrence of meningioma, and WHO grade 2-3 can increase the risk of meningioma recurrence.