Major Vault Protein in Macrophages Reprograms Immune Microenvironment and Inhibits Occurrence and Development of Liver Cancer

• Published in: Zhongliu fangzhi yanjiu Vol. 52; no. 2; pp. 118 - 126
• Main Authors: Zhou, Shimeng, Li, Mengmeng, Wang, Shouyu
• Format: Journal Article
• Language: Chinese; English
• Published: Tianjin China Anti-Cancer Association 01.02.2025; Magazine House of Cancer Research on Prevention and Treatment
• Subjects: Bioinformatics; CD8 antigen; cd8+ t cell; Cell culture; Cell proliferation; Cloning; Enzyme-linked immunosorbent assay; Flow cytometry; Fluorescence; Leukocyte migration; Liver cancer; Lymphocytes; Lymphocytes T; macrophage; Macrophages; major vault protein; Molecular modelling; Proteins; Staining; Tumor cells; Tumor microenvironment; Tumorigenesis; Tumors

Objective　 To explore the role and molecular mechanism of major vault protein (MVP) in tumorassociated macrophages in the occurrence and development of liver cancer. Methods　The expression of MVP in macrophages was analyzed by bioinformatics method and multi-fluorescent immunohistochemical staining....