Mendelian Randomized Study of Protective Effect of Statins on Breast Cancer

• Published in: Zhongliu fangzhi yanjiu Vol. 52; no. 2; pp. 165 - 171
• Main Authors: Hu, Di, Shui, Yifang, Miao, Keke, Li, Mengquan
• Format: Journal Article
• Language: Chinese; English
• Published: Tianjin China Anti-Cancer Association 01.02.2025; Magazine House of Cancer Research on Prevention and Treatment
• Subjects: Breast cancer; Cholesterol; Exposure; Gene mapping; Genes; Genetic effects; Genome-wide association studies; High density lipoprotein; hmgcr; Low density lipoprotein; mendelian randomization; Quantitative trait loci; Randomization; Regulation; Risk; Statins

Objective　To genetically investigate the protective effects of statins on breast cancer. Methods　Instrumental variables for the statin target gene HMGCR and five other cholesterol-regulated genes (LDLR, PCSK9, ABCG8, APOB, and NPC1L1) were obtained from previous expression quantitative trait locus (...