New C3H Kit N824K/WT cancer mouse model develops late-onset malignant mammary tumors with high penetrance

• Published in: Scientific reports Vol. 12; no. 1; pp. 19793 - 15
• Main Authors: Klein-Rodewald, Tanja, Micklich, Kateryna, Sanz-Moreno, Adrián, Tost, Monica, Calzada-Wack, Julia, Adler, Thure, Klaften, Matthias, Sabrautzki, Sibylle, Aigner, Bernhard, Kraiger, Markus, Gailus-Durner, Valerie, Fuchs, Helmut, Gründer, Albert, Pahl, Heike, Wolf, Eckhard, Hrabe de Angelis, Martin, Rathkolb, Birgit
• Format: Journal Article
• Language: English
• Published: England Nature Portfolio 17.11.2022
• Subjects: Animals; Breast Neoplasms - genetics; Disease Models, Animal; Female; Gastrointestinal Stromal Tumors - genetics; Humans; Mice; Mice, Inbred C3H; Penetrance; Proto-Oncogene Proteins c-kit - genetics

Gastro-intestinal stromal tumors and acute myeloid leukemia induced by activating stem cell factor receptor tyrosine kinase (KIT) mutations are highly malignant. Less clear is the role of KIT mutations in the context of breast cancer. Treatment success of KIT-induced cancers is still unsatisfactory...