PCK1 and SLC22A2 gene variants associated with response to metformin treatment in type 2 diabetes - St-Amour, Sophie; Tessier, Laurence; Harnois, Janie; Allard, Catherine; Lavoie, Alexandre; Caron, Philippe; Bouchard, Luigi; Perron, Patrice; Tremblay, Karine (PloS one, 2025)
Keywords: Acidosis; Aged; Analysis; Biology and Life Sciences; Care and treatment; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - genetics; Dosage and administration; Drug therapy; Enzymes; Female; Genes; Genetic aspects; Genetic variation; Genotype; Genotype & phenotype; Genotypes; Genotyping; Glucose; Homeostasis; Humans; Hypoglycemic agents; Hypoglycemic Agents - therapeutic use; Insulin resistance; Intracellular Signaling Peptides and Proteins - genetics; Kinases; Lifestyles; Linkage disequilibrium; Male; Medicine and Health Sciences; Metformin; Metformin - adverse effects; Metformin - therapeutic use; Methods; Middle Aged; Organic Cation Transporter 2 - genetics; Patient compliance; Pharmacology; Phosphoenolpyruvate Carboxykinase (GTP); Polymorphism, Single Nucleotide; Research and Analysis Methods; Side effects; Type 2 diabetes; Canada