Allergenic lipid transfer proteins from plant-derived foods do not immunologically and clinically behave homogeneously: the kiwifruit LTP as a model

• Published in: PloS one Vol. 6; no. 11; p. e27856
• Main Authors: Bernardi, Maria Livia, Giangrieco, Ivana, Camardella, Laura, Ferrara, Rosetta, Palazzo, Paola, Panico, Maria Rosaria, Crescenzo, Roberta, Carratore, Vito, Zennaro, Danila, Liso, Marina, Santoro, Mario, Zuzzi, Sara, Tamburrini, Maurizio, Ciardiello, Maria Antonietta, Mari, Adriano
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.11.2011; Public Library of Science (PLoS)
• Subjects: Acids; Actinidia - immunology; Actinidia - metabolism; Actinidia chinensis; Actinidia deliciosa; Adolescent; Adult; Allergens; Allergens - metabolism; Allergies; Allergy; Amino Acid Sequence; Amino acids; Analysis; Antigenic determinants; Antigens, Plant - metabolism; Biochemistry; Biology; Biomarkers - metabolism; Carrier Proteins - metabolism; Chromatography, High Pressure Liquid; Comparative analysis; Dermatitis; Diagnosis; Double-Blind Method; Epitopes; Female; Food; Food allergies; Food hypersensitivity; Food Hypersensitivity - immunology; Food Hypersensitivity - metabolism; Food plants; Fruit - chemistry; Gene Expression Profiling; Heterogeneity; Homology; Humans; Immune response; Immune system; Immunoglobulin E; Immunoglobulin E - metabolism; Immunology; Information technology; Kiwifruit; Laboratories; Lipid transfer proteins; Lipids; Localization; Male; Mass spectrometry; Medicine; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Patients; Plant Proteins - metabolism; Plants; Plants (botany); Proteins; Recognition; Scientific imaging; Sequence Homology, Amino Acid; Sequences; Skin Tests; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Italy

Food allergy is increasingly common worldwide. Tools for allergy diagnosis measuring IgE improved much since allergenic molecules and microarrays started to be used. IgE response toward allergens belonging to the same group of molecules has not been comprehensively explored using such approach yet....