miRNA‐106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation

• Published in: Molecular oncology Vol. 12; no. 8; pp. 1324 - 1341
• Main Authors: Hoey, Christianne, Ray, Jessica, Jeon, Jouhyun, Huang, Xiaoyong, Taeb, Samira, Ylanko, Jarkko, Andrews, David W., Boutros, Paul C., Liu, Stanley K.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.08.2018; John Wiley and Sons Inc; Wiley
• Subjects: Analysis; Ataxia Telangiectasia Mutated Proteins - genetics; ATM; Cancer; Cell Line, Tumor; Development and progression; Gene expression; Gene Expression Regulation, Neoplastic - radiation effects; Genes; Genetic aspects; Genomes; Genomics; Health aspects; Humans; KU‐55933; LITAF; Male; MicroRNA; MicroRNAs - genetics; miR‐106a; Neoplasm Recurrence, Local - genetics; Nuclear Proteins - genetics; Oncology, Experimental; Prostate cancer; Prostatic Neoplasms - genetics; Prostatic Neoplasms - radiotherapy; Radiation; radiation resistance; Radiotherapy; Scientific equipment and supplies industry; Transcription Factors - genetics; Tumor necrosis factor; Up-Regulation - radiation effects; Canada; United States; Ontario; KU-55933; prostate cancer; ATM; radiation resistance; LITAF; miR-106a

Recurrence of high‐grade prostate cancer after radiotherapy is a significant clinical problem, resulting in increased morbidity and reduced patient survival. The molecular mechanisms of radiation resistance are being elucidated through the study of microRNA (miR) that negatively regulate gene expres...