APOBEC3C‐mediated NF‐κB activation enhances clear cell renal cell carcinoma progression - Hase, Nora; Misiak, Danny; Taubert, Helge; Hüttelmaier, Stefan; Gekle, Michael; Köhn, Marcel (Molecular oncology, 2025)
Keywords: Animals; APOBEC3C; Apolipoproteins; Carcinoma, Renal cell; Carcinoma, Renal Cell - genetics; Carcinoma, Renal Cell - metabolism; Carcinoma, Renal Cell - pathology; ccRCC; Cell activation; Cell Line, Tumor; Cell survival; Cells; Clear cell-type renal cell carcinoma; Cloning; CRISPR; Cytidine Deaminase - genetics; Cytidine Deaminase - metabolism; Cytoplasm; Development and progression; Disease Progression; Enzymes; Gene expression; Gene Expression Regulation, Neoplastic; Genes; Genomes; Genomics; Humans; Hypoxia; Immune system; Immunotherapy; Inflammation; Kidney cancer; Kidney Neoplasms - genetics; Kidney Neoplasms - metabolism; Kidney Neoplasms - pathology; Messenger RNA; Metastases; Mice; Mice, Nude; Molecular modelling; Mutation; NF-kappa B - metabolism; NF-κB Signalling; NF‐κB; Phosphorylation; Plasmids; Protein binding; Proteins; RBP; Renal Cancer; RNA editing; RNA sequencing; RNA-binding protein; Signal Transduction; Transcription factors; Tumor cell lines; Tumors; United States; Germany; Newfoundland and Labrador; United States--US; APOBEC3C; RBP; NF‐κB; ccRCC