The FZD7‐TWIST1 axis is responsible for anoikis resistance and tumorigenesis in ovarian carcinoma

• Published in: Molecular oncology Vol. 13; no. 4; pp. 757 - 780
• Main Authors: Tan, Ming, Asad, Mohammad, Heong, Valerie, Wong, Meng Kang, Tan, Tuan Zea, Ye, Jieru, Kuay, Kuee Theng, Thiery, Jean Paul, Scott, Clare, Huang, Ruby Yun‐Ju
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.04.2019; John Wiley and Sons Inc; Wiley
• Subjects: Acyltransferases - antagonists & inhibitors; Acyltransferases - metabolism; Animals; Anoikis; Base Sequence; BCL2; Carcinogenesis - metabolism; Carcinogenesis - pathology; Cell death; Cell Line, Tumor; Chickens; Development and progression; Down-Regulation - genetics; Epigenesis, Genetic; Epithelial Cells - metabolism; Epithelial-Mesenchymal Transition - genetics; Female; Frizzled Receptors - metabolism; FZD7; Gene Expression Regulation, Neoplastic; Health aspects; Humans; Membrane Proteins - antagonists & inhibitors; Membrane Proteins - metabolism; Mesoderm - pathology; Nuclear Proteins - metabolism; Ovarian cancer; ovarian carcinoma; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Phenotype; Promoters (Genetics); Proto-Oncogene Proteins c-bcl-2 - metabolism; Signal Transduction; Stem cells; Survival Analysis; Treatment Outcome; tumorigenesis; Twist-Related Protein 1 - metabolism; TWIST1; BCL2; ovarian carcinoma; anoikis; TWIST1; tumorigenesis; FZD7

Frizzled family receptor 7 (FZD7), a Wnt signaling receptor, is associated with the maintenance of stem cell properties and cancer progression. FZD7 has emerged as a potential therapeutic target because it is capable of transducing both canonical and noncanonical Wnt signals. In this study, we inves...