Interleukin-1 alpha gene polymorphism (IL-1α) and susceptibility to tinnitus in the elderly

• Published in: Noise & health Vol. 21; no. 99; pp. 77 - 82
• Main Authors: Marchiori, Luciana Lozza de, Doi, Marcelo, Marchiori, Glória de, de Souza, Glenda, Poli-Frederico, Regina, Ciquinato, Daiane Soares de
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.03.2019; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Age; Aged; Aged, 80 and over; Aging; Alleles; Analysis; Biblical literature; Brazil - epidemiology; Case-Control Studies; Chi-square test; Cytokines; Deoxyribonucleic acid; Disease; Disease susceptibility; DNA; Ear; Enzymes; Exposure; Female; Gender; Gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease - epidemiology; Genetic testing; Geriatrics; Humans; Inflammation; Inflammatory response; Interleukin 1; Interleukin-1alpha - genetics; Interleukins; Male; Noise; Noise levels; Noise, Occupational - adverse effects; Nucleotides; occupational; Occupational exposure; Older people; Original; Pathogenesis; Patients; Polymerase chain reaction; Polymorphism; Polymorphism, Single Nucleotide - genetics; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Statistical analysis; Statistical tests; Tinnitus; Tinnitus - epidemiology; Tinnitus - genetics; Viral infections; Brazil; noise; Cytokines; occupational; tinnitus

Aim: To investigate the association between the single nucleotide polymorphism in the position-889 (C/T) of the promoter region of the IL-1α gene and the susceptibility to tinnitus. Method: This was a case-control study with a sample of 108 independent elderly people over 60 years of age. Informatio...